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Medicines > classes : Benzodiazepine or [[:Category:Anti-inflammatories|Anti-inflammatory]] & routes: Oral

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generic:
Alprazolam (1) · Mesalamine (5-aminosalicylic acid, 5-ASA) (1)
brand:
Asacol HD, Pentasa, Lialda, Apriso, Delzicol, Rowasa (rectal), Canasa (suppository) (1) · Xanax (1)
classes: (Click arrow to add another value)
mechanism:
None (1) · GABA-A positive allosteric modulator'"`UNIQ--ref-00000067-QINU`"' '"`UNIQ--vote-00000068-QINU`"' (1)
uses:
'"`UNIQ--vote-00000069-QINU`"', '"`UNIQ--vote-0000006A-QINU`"', '"`UNIQ--vote-0000006B-QINU`"' (1) · '"`UNIQ--vote-00000BBC-QINU`"', '"`UNIQ--vote-00000BBD-QINU`"' (1)
starting dose:
0.25 mg (1) · Active UC: Lialda 2.4-4.8 g PO once daily, Apriso 1.5 g PO once daily; maintenance 1.2-2.4 g/d; rectal Rowasa enema 4 g HS for distal disease; Canasa 1 g suppository HS for proctitis (1)
preparations:
0.25 mg, 0.5 mg, 1 mg, 2 mg tablets (immediate-release and orally disintegrating); 0.5 mg, 1 mg, 2 mg, 3 mg extended-release tablets; 1 mg/mL oral concentrate (1) · Multiple non-bioequivalent oral formulations (pH-, time-, and moisture-dependent release); rectal enema 4 g/60 mL; 1 g rectal suppository (1)
fda max:
10 mg/d (1) · Formulation-specific; ~4.8 g/d typical maximum oral (1)
routes: (Click arrow to add another value)
onset:
30-60 min (immediate-release); 1-2 h (extended-release) (1) · Symptomatic improvement 2-4 weeks (1)
duration:
24 hours (most ER formulations) (1) · 6 h (immediate-release); ~11 h (extended-release) (1)
halflife:
11-13 h (immediate-release); 11-16 h (extended-release) (1) · ~5-10 hours (5-ASA)'"`UNIQ--ref-00000BBE-QINU`"' (1)
bioavailability:
80-90% oral (1) · Highly formulation-dependent; the goal is colonic delivery with minimal systemic exposure'"`UNIQ--ref-00000BBF-QINU`"' (1)
pregnancy:
Category D'"`UNIQ--ref-0000006C-QINU`"' (1) · Generally considered safe at standard doses; benefits typically outweigh in active IBD.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
Schedule IV (US) (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

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