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Drilldown: Medicines

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Medicines > classes : Benzodiazepine or [[:Category:Antifolates|Antifolate]]

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generic:
Alprazolam (1) · Bromazepam (1) · Chlordiazepoxide (1) · Clobazam (1) · Clonazolam (1) · Clorazepate (1) · Diclazepam (1) · Estazolam (1) · Flualprazolam (1) · Flubromazepam (1) · Flubromazolam (1) · Flunitrazepam (1) · Flunitrazolam (1) · Flurazepam (1) · Lormetazepam (1) · Methotrexate (1) · Midazolam (1) · Nifoxipam (1) · Nitrazepam (1) · Oxazepam (1) · Pyrazolam (1) · Quazepam (1) · Temazepam (1) · Triazolam (1)
brand:
None (9) · Dalmane (1) · Doral (1) · Halcion (1) · Lexotan (1) · Librium (1) · Mogadon (1) · Onfi (1) · ProSom (1) · Restoril (1) · Rohypnol (1) · Serax (1) · Tranxene (1) · Trexall, Otrexup, Rasuvo, Xatmep, Rheumatrex (discontinued) (1) · Versed (1) · Xanax (1)
classes: (Click arrow to add another value)
mechanism:
None (1) · Extremely potent GABAA positive allosteric modulator (1) · GABA-A positive allosteric modulator'"`UNIQ--ref-00000067-QINU`"' '"`UNIQ--vote-00000068-QINU`"' (1) · GABAA positive allosteric modulator (18) · GABAA positive allosteric modulator; low sedation (1) · GABAA positive allosteric modulator; prodrug of desmethyldiazepam (1) · GABAA positive allosteric modulator; very long half-life (1)
uses:
None (22) · '"`UNIQ--vote-00000069-QINU`"', '"`UNIQ--vote-0000006A-QINU`"', '"`UNIQ--vote-0000006B-QINU`"' (1) · '"`UNIQ--vote-000007C1-QINU`"', '"`UNIQ--vote-000007C2-QINU`"', '"`UNIQ--vote-000007C3-QINU`"', '"`UNIQ--vote-000007C4-QINU`"', '"`UNIQ--vote-000007C5-QINU`"', '"`UNIQ--vote-000007C6-QINU`"', '"`UNIQ--vote-000007C7-QINU`"' (1)
starting dose:
None (22) · 0.25 mg (1) · Rheumatologic: 7.5-15 mg PO or SC '''once weekly''' (not daily — daily dosing is a recognized fatal error); folic acid 1 mg PO daily on non-MTX days; oncology dosing is far higher and indication-specific (1)
preparations:
None (22) · 0.25 mg, 0.5 mg, 1 mg, 2 mg tablets (immediate-release and orally disintegrating); 0.5 mg, 1 mg, 2 mg, 3 mg extended-release tablets; 1 mg/mL oral concentrate (1) · 2.5 mg tablets; 10-50 mg/mL injection; pre-filled subcutaneous autoinjectors (Otrexup, Rasuvo); 2.5 mg/mL oral solution (Xatmep) (1)
fda max:
None (22) · 10 mg/d (1) · Rheumatologic ~25 mg/week; oncology indication-specific (1)
routes:
None (22) · intramuscular (1) · intrathecal (1) · IV (1) · Oral (2) · subcutaneous (1)
onset:
None (22) · 30-60 min (immediate-release); 1-2 h (extended-release) (1) · Rheumatologic effect at 4-8 weeks; ectopic resolution over 2-3 weeks (1)
duration:
None (22) · 6 h (immediate-release); ~11 h (extended-release) (1) · Once-weekly dosing in rheumatology (1)
halflife:
None (22) · 11-13 h (immediate-release); 11-16 h (extended-release) (1) · 3-10 hours (low dose); 8-15 hours (high dose); much longer in third-space accumulation (pleural effusion, ascites)'"`UNIQ--ref-000007C8-QINU`"' (1)
bioavailability:
None (22) · 60-70% PO at low doses; saturable at high doses (parenteral routes preferred above 15-25 mg/week)'"`UNIQ--ref-000007C9-QINU`"' (1) · 80-90% oral (1)
pregnancy:
None (22) · '''Contraindicated in pregnancy''' (Category X); abortifacient and teratogenic. Discontinuation 3-6 months before conception is standard.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1) · Category D'"`UNIQ--ref-0000006C-QINU`"' (1)
legal:
None (22) · Schedule IV (US) (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

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