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Medicines > classes : Benzodiazepine or [[:Category:Antihistamines|First-generation antihistamine (piperazine)]] & routes: oral

Use the filters below to narrow your results.

generic:
Alprazolam (1) · Meclizine (1)
brand:
Antivert (Rx), Bonine (OTC), Dramamine Less Drowsy (OTC) (1) · Xanax (1)
classes: (Click arrow to add another value)
mechanism:
GABA-A positive allosteric modulator'"`UNIQ--ref-00000067-QINU`"' '"`UNIQ--vote-00000068-QINU`"' (1) · '"`UNIQ--vote-00000013-QINU`"' Anticholinergic burden (dry mouth, blurred vision, urinary retention, cognitive effects) is the principal adverse-event concern and the basis for Beers-list cautions in elderly patients'"`UNIQ--ref-00000014-QINU`"'. (1)
uses:
'"`UNIQ--vote-00000015-QINU`"', '"`UNIQ--vote-00000016-QINU`"', '"`UNIQ--vote-00000017-QINU`"' (1) · '"`UNIQ--vote-00000069-QINU`"', '"`UNIQ--vote-0000006A-QINU`"', '"`UNIQ--vote-0000006B-QINU`"' (1)
starting dose:
0.25 mg (1) · Motion sickness: 25-50 mg PO 1 hour before travel, repeat every 24 hours as needed. Vertigo: 25-100 mg/day divided (1)
preparations:
0.25 mg, 0.5 mg, 1 mg, 2 mg tablets (immediate-release and orally disintegrating); 0.5 mg, 1 mg, 2 mg, 3 mg extended-release tablets; 1 mg/mL oral concentrate (1) · Tablets 12.5, 25 mg; chewable tablets 25 mg (1)
fda max:
10 mg/d (1) · 100 mg/day (vertigo) (1)
routes: (Click arrow to add another value)
onset:
30-60 min (immediate-release); 1-2 h (extended-release) (1) · ~1 hour (1)
duration:
12-24 hours (long for an antihistamine) (1) · 6 h (immediate-release); ~11 h (extended-release) (1)
halflife:
11-13 h (immediate-release); 11-16 h (extended-release) (1) · ~6 hours'"`UNIQ--ref-00000018-QINU`"' (1)
bioavailability:
80-90% oral (1) · ~25% (oral)'"`UNIQ--ref-00000019-QINU`"' (1)
pregnancy:
Category D'"`UNIQ--ref-0000006C-QINU`"' (1) · Older agent with substantial use experience; observational signals reassuring for first-trimester exposure.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
Schedule IV (US) (1) · [[USLegal:Over-the-counter|OTC]] as Bonine and Dramamine Less Drowsy; [[USLegal:Prescription only|Rx-only]] as Antivert (1)

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