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Medicines > classes : Benzodiazepine or [[:Category:Calcium_supplements|Calcium supplement]] & routes: Oral

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generic:
Alprazolam (1) · Calcium (carbonate, citrate, gluconate, chloride salts) (1)
brand:
Tums, Caltrate, Os-Cal, Citracal; many generics (1) · Xanax (1)
classes: (Click arrow to add another value)
mechanism:
None (1) · GABA-A positive allosteric modulator'"`UNIQ--ref-00000067-QINU`"' '"`UNIQ--vote-00000068-QINU`"' (1)
uses:
'"`UNIQ--vote-00000069-QINU`"', '"`UNIQ--vote-0000006A-QINU`"', '"`UNIQ--vote-0000006B-QINU`"' (1) · '"`UNIQ--vote-000012B7-QINU`"', '"`UNIQ--vote-000012B8-QINU`"', '"`UNIQ--vote-000012B9-QINU`"', '"`UNIQ--vote-000012BA-QINU`"', '"`UNIQ--vote-000012BB-QINU`"' (1)
starting dose:
0.25 mg (1) · Oral: 1000-1500 mg elemental calcium/day in divided doses for supplementation; IV gluconate 1 g (4.65 mEq) over 5-10 min for hyperkalemia or symptomatic hypocalcemia (1)
preparations:
0.25 mg, 0.5 mg, 1 mg, 2 mg tablets (immediate-release and orally disintegrating); 0.5 mg, 1 mg, 2 mg, 3 mg extended-release tablets; 1 mg/mL oral concentrate (1) · Carbonate 200, 400, 500, 600 mg elemental tablets and chewables; citrate 200, 250, 315 mg elemental; gluconate 1 g (94 mg elemental, 4.65 mEq) IV; chloride 1 g (270 mg elemental, 13.6 mEq) IV (1)
fda max:
10 mg/d (1) · ~2500 mg elemental/d combined diet + supplements (chronic; UL) (1)
routes: (Click arrow to add another value)
onset:
30-60 min (immediate-release); 1-2 h (extended-release) (1) · Acute: minutes (IV); chronic: bone effect over months (1)
duration:
6 h (immediate-release); ~11 h (extended-release) (1) · Variable (1)
halflife:
11-13 h (immediate-release); 11-16 h (extended-release) (1) · Not meaningfully described (electrolyte) (1)
bioavailability:
80-90% oral (1) · Carbonate ~30-40% (best with food and acid); citrate ~24% (absorbable without acid; preferred in achlorhydria, PPI use, post-bariatric) (1)
pregnancy:
Category D'"`UNIQ--ref-0000006C-QINU`"' (1) · Routinely supplemented in pregnancy; needs higher in pregnancy and lactation.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
OTC (oral supplements) and [[USLegal:Prescription only|Rx-only]] (IV) in US (1) · Schedule IV (US) (1)

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