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Medicines > classes : Benzodiazepine or [[:Category:Diphenylmethane_laxatives|Diphenylmethane laxative]] & routes: Oral

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generic:
Alprazolam (1) · Bisacodyl (1)
brand:
Dulcolax, Correctol, Bisac-Evac (1) · Xanax (1)
classes: (Click arrow to add another value)
mechanism:
GABA-A positive allosteric modulator'"`UNIQ--ref-00000067-QINU`"' '"`UNIQ--vote-00000068-QINU`"' (1) · '"`UNIQ--vote-00001067-QINU`"' Chronic use is associated with cathartic colon (colonic dilation, loss of haustration), hypokalemia, and laxative dependence; reserved for short-term use or bowel prep with breaks between courses'"`UNIQ--ref-00001068-QINU`"'. (1)
uses:
'"`UNIQ--vote-00000069-QINU`"', '"`UNIQ--vote-0000006A-QINU`"', '"`UNIQ--vote-0000006B-QINU`"' (1) · '"`UNIQ--vote-00001069-QINU`"', '"`UNIQ--vote-0000106A-QINU`"' (1)
starting dose:
0.25 mg (1) · 5-15 mg PO once at bedtime; 10 mg PR for faster effect; bowel prep regimens use higher single doses (1)
preparations:
0.25 mg, 0.5 mg, 1 mg, 2 mg tablets (immediate-release and orally disintegrating); 0.5 mg, 1 mg, 2 mg, 3 mg extended-release tablets; 1 mg/mL oral concentrate (1) · 5 mg enteric-coated tablets; 10 mg rectal suppositories; OTC and Rx (1)
fda max:
10 mg/d (1) · 30 mg/d for short-term use (1)
routes: (Click arrow to add another value)
onset:
30-60 min (immediate-release); 1-2 h (extended-release) (1) · PO 6-12 hours; PR 15-60 minutes (1)
duration:
6 h (immediate-release); ~11 h (extended-release) (1) · Hours (1)
halflife:
11-13 h (immediate-release); 11-16 h (extended-release) (1) · Variable; effect dependent on local intestinal action rather than systemic kinetics'"`UNIQ--ref-0000106B-QINU`"' (1)
bioavailability:
80-90% oral (1) · Low systemic absorption (enteric coating delivers drug to colon)'"`UNIQ--ref-0000106C-QINU`"' (1)
pregnancy:
Category D'"`UNIQ--ref-0000006C-QINU`"' (1) · Generally considered acceptable for short-term use.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
OTC in US (1) · Schedule IV (US) (1)

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