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Medicines > classes : Benzodiazepine or [[:Category:Schedule V controlled substances|Schedule V controlled substance]] & routes: Oral

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generic:
Alprazolam (1) · Pregabalin (1)
brand:
Lyrica (IR), Lyrica CR (1) · Xanax (1)
classes: (Click arrow to add another value)
mechanism:
None (1) · GABA-A positive allosteric modulator'"`UNIQ--ref-00000067-QINU`"' '"`UNIQ--vote-00000068-QINU`"' (1)
uses:
'"`UNIQ--vote-0000001F-QINU`"', '"`UNIQ--vote-00000020-QINU`"', '"`UNIQ--vote-00000021-QINU`"', '"`UNIQ--vote-00000022-QINU`"', '"`UNIQ--vote-00000023-QINU`"', '"`UNIQ--vote-00000024-QINU`"', '"`UNIQ--vote-00000025-QINU`"' (1) · '"`UNIQ--vote-00000069-QINU`"', '"`UNIQ--vote-0000006A-QINU`"', '"`UNIQ--vote-0000006B-QINU`"' (1)
starting dose:
0.25 mg (1) · Neuropathic pain: 75 mg PO BID, titrate to 150 mg BID after 1 week. Fibromyalgia: 75 mg PO BID, titrate to 150 mg BID. Anxiety (off-label): 75-150 mg/day divided BID-TID (1)
preparations:
0.25 mg, 0.5 mg, 1 mg, 2 mg tablets (immediate-release and orally disintegrating); 0.5 mg, 1 mg, 2 mg, 3 mg extended-release tablets; 1 mg/mL oral concentrate (1) · Capsules 25, 50, 75, 100, 150, 200, 225, 300 mg; oral solution 20 mg/mL; Lyrica CR tablets 82.5, 165, 330 mg (1)
fda max:
10 mg/d (1) · 600 mg/day (seizures); 450 mg/day (fibromyalgia and neuropathic pain) (1)
routes: (Click arrow to add another value)
onset:
30-60 min (immediate-release); 1-2 h (extended-release) (1) · Neuropathic pain and fibromyalgia effect emerges over 1-2 weeks (1)
duration:
6 h (immediate-release); ~11 h (extended-release) (1) · BID-TID dosing for IR; once-daily for CR (1)
halflife:
11-13 h (immediate-release); 11-16 h (extended-release) (1) · 6.3 hours'"`UNIQ--ref-00000026-QINU`"' (1)
bioavailability:
80-90% oral (1) · ≥90% (linear pharmacokinetics, distinguishing it favorably from gabapentin's saturable LAT-1 absorption)'"`UNIQ--ref-00000027-QINU`"' (1)
pregnancy:
Category D'"`UNIQ--ref-0000006C-QINU`"' (1) · Some signal for major congenital malformations; limited human data.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
'''[[USLegal:Schedule V|Schedule V controlled substance]] in US (federally)''', distinct from gabapentin which remains federally unscheduled'"`UNIQ--ref-00000028-QINU`"' (1) · Schedule IV (US) (1)

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