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Drilldown: Medicines

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Medicines > classes : Benzodiazepine or Classic Psychedelic or low-trapping)

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generic:
brand:
None (78) · Dalmane (1) · Delysid (historical, Sandoz, withdrawn 1965) (1) · Doral (1) · Halcion (1) · Lexotan (1) · Librium (1) · Mogadon (1) · Onfi (1) · ProSom (1) · REL-1017 / esmethadone (investigational; not yet FDA-approved as of mid-2024) (1) · Restoril (1) · Rohypnol (1) · Serax (1) · Tranxene (1) · Versed (1) · Xanax (1)
classes: (Click arrow to add another value)
mechanism:
5-HT2A agonist (26) · GABAA positive allosteric modulator (18) · Potent 5-HT2A agonist (5) · LSD analogue; 5-HT2A agonist (4) · Prodrug of LSD; 5-HT2A agonist (4) · Contains LSA (2) · Contains mescaline (2)
uses:
None (92) · Investigational for major depressive disorder; trials underway (phase 3 mixed results) (1) · '"`UNIQ--vote-00000069-QINU`"', '"`UNIQ--vote-0000006A-QINU`"', '"`UNIQ--vote-0000006B-QINU`"' (1)
starting dose:
None (92) · 0.25 mg (1) · Trials use 25 mg or 50 mg PO daily (1)
preparations:
None (92) · 0.25 mg, 0.5 mg, 1 mg, 2 mg tablets (immediate-release and orally disintegrating); 0.5 mg, 1 mg, 2 mg, 3 mg extended-release tablets; 1 mg/mL oral concentrate (1) · Investigational oral capsule (1)
fda max:
None (92) · 10 mg/d (1) · Not yet approved (1)
routes:
None (91) · Oral (3)
onset:
None (91) · 30-60 min (immediate-release); 1-2 h (extended-release) (1) · 30–60 minutes (1) · Rapid (within 1 week in trials) (1)
duration:
None (91) · 6 h (immediate-release); ~11 h (extended-release) (1) · 8–12 hours (1) · Daily dosing (1)
halflife:
None (91) · 11-13 h (immediate-release); 11-16 h (extended-release) (1) · 3–5 hours (1) · Not formally established (1)
bioavailability:
None (91) · 70–90% (oral) (1) · 80-90% oral (1) · Oral bioavailability suitable for daily dosing (1)
pregnancy:
None (91) · Category D'"`UNIQ--ref-0000006C-QINU`"' (1) · Investigational (1) · Not established (1)
legal:
None (91) · Investigational (1) · Schedule I (United States) (1) · Schedule IV (US) (1)

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