Drilldown: Medicines - Pharmacopedia

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Medicines (732)

Medicines > classes

: Benzodiazepine

or D2/D3/5HT1A partial agonist

& routes: Oral

Use the filters below to narrow your results.

None (1) · Alprazolam (1)

Vraylar (1) · Xanax (1)

None (1) · GABA-A positive allosteric modulator'"`UNIQ--ref-00000067-QINU`"' '"`UNIQ--vote-00000068-QINU`"' (1)

Schizophrenia (FDA-approved 2015). Acute manic or mixed episodes of bipolar I disorder. Bipolar I depression (FDA-approved 2019). Adjunctive treatment of major depressive disorder (FDA-approved Dec 2022). (1) · '"`UNIQ--vote-00000069-QINU`"', '"`UNIQ--vote-0000006A-QINU`"', '"`UNIQ--vote-0000006B-QINU`"' (1)

0.25 mg (1) · Schizophrenia: 1.5 mg PO daily, increase to 1.5-6 mg as tolerated. Bipolar mania: 1.5 mg, may increase to 3-6 mg. Bipolar depression: 1.5 mg daily for 14 days, then 3 mg. MDD adjunct: 1.5 mg, may increase to 3 mg. (1)

0.25 mg, 0.5 mg, 1 mg, 2 mg tablets (immediate-release and orally disintegrating); 0.5 mg, 1 mg, 2 mg, 3 mg extended-release tablets; 1 mg/mL oral concentrate (1) · 1.5 mg, 3 mg, 4.5 mg, 6 mg capsules (1)

10 mg/d (1) · 6 mg/d (psychosis/mania); 3 mg/d (depression adjunct) (1)

30-60 min (immediate-release); 1-2 h (extended-release) (1) · Weeks for psychosis/mood efficacy (1)

6 h (immediate-release); ~11 h (extended-release) (1) · Daily dosing; active metabolites with very long half-lives (up to 1-3 weeks) (1)

11-13 h (immediate-release); 11-16 h (extended-release) (1) · Cariprazine ~2-4 d; major active metabolites desmethyl-cariprazine (DCAR) ~1-3 weeks → 'oral depot' effect with delayed steady-state and reduced effect of missed doses (1)

80-90% oral (1) · Adequate oral bioavailability (1)

Category D'"`UNIQ--ref-0000006C-QINU`"' (1) · Limited data (1)

Rx (1) · Schedule IV (US) (1)

Showing below up to 2 results in range #1 to #2.

A

Alprazolam

C

Cariprazine

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