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Medicines > classes : Benzodiazepine or Empathogen or [[:Category:Biguanides|Biguanide]]

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generic:
brand:
None (25) · Dalmane (1) · Doral (1) · Glucophage, Glucophage XR, Fortamet, Glumetza, Riomet (1) · Halcion (1) · Lexotan (1) · Librium (1) · Mogadon (1) · Onfi (1) · ProSom (1) · Restoril (1) · Rohypnol (1) · Serax (1) · Tranxene (1) · Versed (1) · Xanax (1)
classes: (Click arrow to add another value)
mechanism:
Extremely potent GABAA positive allosteric modulator (1) · GABA-A positive allosteric modulator'"`UNIQ--ref-00000067-QINU`"' '"`UNIQ--vote-00000068-QINU`"' (1) · GABAA positive allosteric modulator (18) · GABAA positive allosteric modulator; low sedation (1) · GABAA positive allosteric modulator; prodrug of desmethyldiazepam (1) · GABAA positive allosteric modulator; very long half-life (1) · MAO inhibitor; monoamine releasing agent (1) · MAO inhibitor; serotonin releasing agent (1) · Monoamine releasing agent (3) · Monoamine releasing agent; 5-HT2A agonist (1) · Monoamine releasing agent; serotonergic at higher doses (1) · Serotonin releasing agent (2) · Serotonin releasing agent; 5-HT2A agonist (3) · Serotonin/dopamine/norepinephrine releasing agent; 5-HT2A agonist (1) · Serotonin/norepinephrine/dopamine releasing agent (3) · '"`UNIQ--vote-00000013-QINU`"' Does not stimulate insulin secretion; minimal hypoglycemia risk as monotherapy. Cleared renally unchanged; dose-adjust by eGFR'"`UNIQ--ref-00000014-QINU`"'. Rare lactic acidosis primarily in renal failure or acute illness. (1)
uses:
None (38) · '"`UNIQ--vote-00000015-QINU`"', '"`UNIQ--vote-00000016-QINU`"', '"`UNIQ--vote-00000017-QINU`"' (1) · '"`UNIQ--vote-00000069-QINU`"', '"`UNIQ--vote-0000006A-QINU`"', '"`UNIQ--vote-0000006B-QINU`"' (1)
starting dose:
None (38) · 0.25 mg (1) · 500 mg PO once or twice daily with meals; titrate weekly to limit GI effects (1)
preparations:
None (38) · 0.25 mg, 0.5 mg, 1 mg, 2 mg tablets (immediate-release and orally disintegrating); 0.5 mg, 1 mg, 2 mg, 3 mg extended-release tablets; 1 mg/mL oral concentrate (1) · 500 mg, 850 mg, 1000 mg IR tablets; 500 mg, 750 mg, 1000 mg ER tablets; 500 mg/5 mL oral solution (1)
fda max:
None (38) · 10 mg/d (1) · 2550 mg/d (IR); 2000 mg/d (ER) (1)
routes:
None (38) · Oral (2)
onset:
None (38) · 30-60 min (immediate-release); 1-2 h (extended-release) (1) · Glucose lowering within days; HbA1c effect at 8-12 weeks (1)
duration:
None (38) · 6 h (immediate-release); ~11 h (extended-release) (1) · ~12 hours (IR); 24 hours (ER) (1)
halflife:
None (38) · 11-13 h (immediate-release); 11-16 h (extended-release) (1) · 6.2 hours (plasma); ~17 hours in erythrocytes'"`UNIQ--ref-00000018-QINU`"' (1)
bioavailability:
None (38) · 50-60% (oral; decreased with food, but food given anyway for GI tolerance)'"`UNIQ--ref-00000019-QINU`"' (1) · 80-90% oral (1)
pregnancy:
None (38) · Category D'"`UNIQ--ref-0000006C-QINU`"' (1) · Generally considered safe; widely used in PCOS and gestational diabetes; placental transfer occurs.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
None (38) · Schedule IV (US) (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

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