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Drilldown: Medicines

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Medicines > classes : Benzodiazepine or Neuroactive steroid & routes: Oral

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generic:
None (1) · Alprazolam (1)
brand:
Xanax (1) · Zurzuvae (1)
classes: (Click arrow to add another value)
mechanism:
GABA-A positive allosteric modulator'"`UNIQ--ref-00000067-QINU`"' '"`UNIQ--vote-00000068-QINU`"' (1) · Synthetic neuroactive steroid (an analog of allopregnanolone), bioavailable orally unlike brexanolone. Positive allosteric modulator at GABA-A receptors including extrasynaptic δ-containing subtypes. (1)
uses:
Postpartum depression (PPD) in adults (FDA-approved 2023) (1) · '"`UNIQ--vote-00000069-QINU`"', '"`UNIQ--vote-0000006A-QINU`"', '"`UNIQ--vote-0000006B-QINU`"' (1)
starting dose:
0.25 mg (1) · 50 mg PO once daily with fatty food in the evening × 14 days (1)
preparations:
0.25 mg, 0.5 mg, 1 mg, 2 mg tablets (immediate-release and orally disintegrating); 0.5 mg, 1 mg, 2 mg, 3 mg extended-release tablets; 1 mg/mL oral concentrate (1) · 20 mg, 25 mg, 30 mg capsules (1)
fda max:
10 mg/d (1) · 50 mg/d × 14 d (1)
routes: (Click arrow to add another value)
onset:
30-60 min (immediate-release); 1-2 h (extended-release) (1) · Day 3 of dosing in trials; sustained through day 45 (1)
duration:
14-day course; effect persists after discontinuation in trials (1) · 6 h (immediate-release); ~11 h (extended-release) (1)
halflife:
11-13 h (immediate-release); 11-16 h (extended-release) (1) · ~16-23 hours (1)
bioavailability:
80-90% oral (1) · Adequate (food-dependent, must take with fatty meal) (1)
pregnancy:
Category D'"`UNIQ--ref-0000006C-QINU`"' (1) · Limited data; avoid in pregnancy. Lactation: present in milk; consider risks (1)
legal:
Rx, Schedule IV (US) (1) · Schedule IV (US) (1)

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