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Drilldown: Medicines

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Medicines > classes : Benzodiazepine or Non-selective & routes: Oral

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generic:
Alprazolam (1) · Propranolol (1)
brand:
Inderal (1) · Xanax (1)
classes: (Click arrow to add another value)
mechanism:
GABA-A positive allosteric modulator'"`UNIQ--ref-00000067-QINU`"' '"`UNIQ--vote-00000068-QINU`"' (1) · Non-selective competitive antagonist at β1 and β2 adrenergic receptors. Lipophilic; significant blood–brain barrier penetration, accounting for its CNS effects. (1)
uses:
'"`UNIQ--vote-00000069-QINU`"', '"`UNIQ--vote-0000006A-QINU`"', '"`UNIQ--vote-0000006B-QINU`"' (1) · '"`UNIQ--vote-000005E7-QINU`"', '"`UNIQ--vote-000005E8-QINU`"', '"`UNIQ--vote-000005E9-QINU`"', '"`UNIQ--vote-000005EA-QINU`"', '"`UNIQ--vote-000005EB-QINU`"' (1)
starting dose:
0.25 mg (1) · 10–40 mg (situational anxiety); 40 mg BID (HTN) (1)
preparations:
0.25 mg, 0.5 mg, 1 mg, 2 mg tablets (immediate-release and orally disintegrating); 0.5 mg, 1 mg, 2 mg, 3 mg extended-release tablets; 1 mg/mL oral concentrate (1) · 10, 20, 40, 60, 80 mg tabs; 60/80/120/160 mg ER caps; 1 mg/mL IV (1)
fda max:
10 mg/d (1) · 640 mg/d (HTN); 240 mg/d (migraine) (1)
routes: (Click arrow to add another value)
onset:
1–2 h (PO), immediate (IV) (1) · 30-60 min (immediate-release); 1-2 h (extended-release) (1)
duration:
6 h (immediate-release); ~11 h (extended-release) (1) · 6–12 h (IR); 24 h (ER) (1)
halflife:
11-13 h (immediate-release); 11-16 h (extended-release) (1) · 3–6 h (1)
bioavailability:
80-90% oral (1) · ~25% (extensive hepatic first-pass) (1)
pregnancy:
Category C (1) · Category D'"`UNIQ--ref-0000006C-QINU`"' (1)
legal:
Rx-only in US (1) · Schedule IV (US) (1)

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