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Medicines > classes : Benzodiazepine or Phenethylamine or [[:Category:Dibenzothiazepines|Dibenzothiazepine]]

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generic:
brand:
None (34) · Dalmane (1) · Doral (1) · Halcion (1) · Lexotan (1) · Librium (1) · Mogadon (1) · Nexus, Eroxan (historical, late-1980s through mid-1990s) (1) · Onfi (1) · ProSom (1) · Restoril (1) · Rohypnol (1) · Serax (1) · Seroquel (1) · Tranxene (1) · Versed (1) · Xanax (1)
classes: (Click arrow to add another value)
mechanism:
5-HT2A agonist (12) · 5-HT2A agonist; long duration (1) · 5-HT2A agonist; MAO inhibitor (1) · 5-HT2A agonist; milder than other 2C-x (1) · 5-HT2A partial agonist (1) · Dopamine D2 and serotonin 5-HT2A receptor antagonist'"`UNIQ--ref-0000008D-QINU`"' '"`UNIQ--vote-0000008E-QINU`"' (1) · Extremely potent 5-HT2A agonist; vasoconstrictor (1) · Extremely potent 5-HT2A agonist; very long duration (1) · Extremely potent GABAA positive allosteric modulator (1) · GABA-A positive allosteric modulator'"`UNIQ--ref-00000067-QINU`"' '"`UNIQ--vote-00000068-QINU`"' (1) · GABAA positive allosteric modulator (18) · GABAA positive allosteric modulator; low sedation (1) · GABAA positive allosteric modulator; prodrug of desmethyldiazepam (1) · GABAA positive allosteric modulator; very long half-life (1) · Potent 5-HT2A agonist (5) · Potent 5-HT2A agonist; no oral activity (1) · Potent 5-HT2A agonist; very long duration (1) · Very potent 5-HT2A agonist; long duration (1)
uses:
None (48) · '"`UNIQ--vote-00000069-QINU`"', '"`UNIQ--vote-0000006A-QINU`"', '"`UNIQ--vote-0000006B-QINU`"' (1) · '"`UNIQ--vote-0000008F-QINU`"', '"`UNIQ--vote-00000090-QINU`"', '"`UNIQ--vote-00000091-QINU`"', '"`UNIQ--vote-00000092-QINU`"' (1)
starting dose:
None (48) · 0.25 mg (1) · 25 mg (schizophrenia, immediate-release); 50 mg (bipolar mania, immediate-release); 50 mg (Seroquel XR, schizophrenia or bipolar) (1)
preparations:
None (48) · 0.25 mg, 0.5 mg, 1 mg, 2 mg tablets (immediate-release and orally disintegrating); 0.5 mg, 1 mg, 2 mg, 3 mg extended-release tablets; 1 mg/mL oral concentrate (1) · 25 mg, 50 mg, 100 mg, 200 mg, 300 mg, 400 mg immediate-release tablets; 50 mg, 150 mg, 200 mg, 300 mg, 400 mg extended-release tablets (Seroquel XR) (1)
fda max:
None (48) · 10 mg/d (1) · 800 mg/day (1)
routes:
None (47) · insufflated (1) · Oral (3) · PR (1)
onset:
None (47) · 30-60 min (immediate-release); 1-2 h (extended-release) (1) · 30-60 min (sedation); days to weeks (neuroleptic effect) (1) · 45-75 min (oral) (1)
duration:
None (47) · 4-8 h (1) · 6 h (immediate-release); ~11 h (extended-release) (1) · 6-8 h (immediate-release); 24 h (extended-release) (1)
halflife:
None (47) · 11-13 h (immediate-release); 11-16 h (extended-release) (1) · Not well characterized (1) · ~6 h (parent compound, immediate-release); ~9-12 h (active metabolite N-desalkylquetiapine, also called norquetiapine) (1)
bioavailability:
None (47) · 80-90% oral (1) · Not well characterized (1) · Tablet ~100% relative to oral solution; extensive first-pass metabolism (1)
pregnancy:
None (47) · Category D'"`UNIQ--ref-0000006C-QINU`"' (1) · Not established (1) · Pregnancy categories were retired by FDA in 2015. Quetiapine has reassuring active-comparator cohort data without consistent teratogenic signal; among the preferred neuroleptics when treatment is clinically necessary in pregnancy. See pregnancy_details for the full citation set. (1)
legal:
None (47) · Schedule IV (US) (1) · [[USLegal:DEA Schedule I|Schedule I]] (United States) (1) · [[USLegal:Prescription only|Prescription only]]; not a controlled substance (1)

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