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Medicines > classes : Benzodiazepine or potent non-selective)]] & routes: Oral

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generic:
Alprazolam (1) · Indomethacin (1)
brand:
Indocin (oral, IV, suppository), Tivorbex (low-dose), Indo-Lemmon (1) · Xanax (1)
classes: (Click arrow to add another value)
mechanism:
None (1) · GABA-A positive allosteric modulator'"`UNIQ--ref-00000067-QINU`"' '"`UNIQ--vote-00000068-QINU`"' (1)
uses:
'"`UNIQ--vote-0000001F-QINU`"', '"`UNIQ--vote-00000020-QINU`"', '"`UNIQ--vote-00000021-QINU`"', '"`UNIQ--vote-00000022-QINU`"', '"`UNIQ--vote-00000023-QINU`"', '"`UNIQ--vote-00000024-QINU`"', '"`UNIQ--vote-00000025-QINU`"' (1) · '"`UNIQ--vote-00000069-QINU`"', '"`UNIQ--vote-0000006A-QINU`"', '"`UNIQ--vote-0000006B-QINU`"' (1)
starting dose:
0.25 mg (1) · Acute gout: 50 mg PO TID until symptom relief, then taper; maximum 200 mg/day for 3-5 days. Rheumatoid arthritis / osteoarthritis: 25-50 mg PO BID-TID. Patent ductus arteriosus: 0.2 mg/kg IV, then 0.1-0.2 mg/kg every 12-24 hours for 2 doses (1)
preparations:
0.25 mg, 0.5 mg, 1 mg, 2 mg tablets (immediate-release and orally disintegrating); 0.5 mg, 1 mg, 2 mg, 3 mg extended-release tablets; 1 mg/mL oral concentrate (1) · Capsules 25, 50 mg; ER capsules 75 mg; oral suspension 25 mg/5 mL; suppositories 50 mg; injection 1 mg/vial (PDA closure) (1)
fda max:
10 mg/d (1) · 200 mg/day (typical adult oral) (1)
routes: (Click arrow to add another value)
onset:
30-60 min (immediate-release); 1-2 h (extended-release) (1) · 30-60 minutes (oral); rapid relief in acute gout (1)
duration:
4-6 hours (IR); 24 hours (ER) (1) · 6 h (immediate-release); ~11 h (extended-release) (1)
halflife:
11-13 h (immediate-release); 11-16 h (extended-release) (1) · 4-5 hours'"`UNIQ--ref-00000026-QINU`"' (1)
bioavailability:
80-90% oral (1) · ~100% (oral)'"`UNIQ--ref-00000027-QINU`"' (1)
pregnancy:
Avoid from 20 weeks gestation onward per FDA's 2020 expanded NSAID warning; contraindicated from 30 weeks (risk of premature ductus arteriosus closure, which is paradoxically the basis of the neonatal PDA-closure indication)'"`UNIQ--ref-00000028-QINU`"' (1) · Category D'"`UNIQ--ref-0000006C-QINU`"' (1)
legal:
Schedule IV (US) (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

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