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Medicines > classes : Benzodiazepine or with alpha-1 antagonism)]]

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generic:
Alprazolam (1) · Bromazepam (1) · Carvedilol (1) · Chlordiazepoxide (1) · Clobazam (1) · Clonazolam (1) · Clorazepate (1) · Diclazepam (1) · Estazolam (1) · Flualprazolam (1) · Flubromazepam (1) · Flubromazolam (1) · Flunitrazepam (1) · Flunitrazolam (1) · Flurazepam (1) · Lormetazepam (1) · Midazolam (1) · Nifoxipam (1) · Nitrazepam (1) · Oxazepam (1) · Pyrazolam (1) · Quazepam (1) · Temazepam (1) · Triazolam (1)
brand:
None (9) · Coreg, Coreg CR (1) · Dalmane (1) · Doral (1) · Halcion (1) · Lexotan (1) · Librium (1) · Mogadon (1) · Onfi (1) · ProSom (1) · Restoril (1) · Rohypnol (1) · Serax (1) · Tranxene (1) · Versed (1) · Xanax (1)
classes: (Click arrow to add another value)
mechanism:
Extremely potent GABAA positive allosteric modulator (1) · GABA-A positive allosteric modulator'"`UNIQ--ref-00000067-QINU`"' '"`UNIQ--vote-00000068-QINU`"' (1) · GABAA positive allosteric modulator (18) · GABAA positive allosteric modulator; low sedation (1) · GABAA positive allosteric modulator; prodrug of desmethyldiazepam (1) · GABAA positive allosteric modulator; very long half-life (1) · '"`UNIQ--vote-00000015-QINU`"' CYP2D6 metabolism produces stereoselective clearance; CYP2D6 poor metabolizers have higher plasma exposure and may need lower doses'"`UNIQ--ref-00000016-QINU`"'. (1)
uses:
None (22) · '"`UNIQ--vote-00000017-QINU`"', '"`UNIQ--vote-00000018-QINU`"', '"`UNIQ--vote-00000019-QINU`"', '"`UNIQ--vote-0000001A-QINU`"' (1) · '"`UNIQ--vote-00000069-QINU`"', '"`UNIQ--vote-0000006A-QINU`"', '"`UNIQ--vote-0000006B-QINU`"' (1)
starting dose:
None (22) · 0.25 mg (1) · Heart failure: 3.125 mg PO BID, doubling every 2 weeks as tolerated to target 25 mg BID (50 mg BID if >85 kg). Hypertension: 6.25 mg PO BID, titrate to 25 mg BID (1)
preparations:
None (22) · 0.25 mg, 0.5 mg, 1 mg, 2 mg tablets (immediate-release and orally disintegrating); 0.5 mg, 1 mg, 2 mg, 3 mg extended-release tablets; 1 mg/mL oral concentrate (1) · IR tablets 3.125, 6.25, 12.5, 25 mg; Coreg CR capsules 10, 20, 40, 80 mg (once-daily) (1)
fda max:
None (22) · 10 mg/d (1) · 50 mg BID in heart failure (or once-daily equivalent CR); 25 mg BID in hypertension (1)
routes:
None (22) · Oral (2)
onset:
None (22) · 30-60 min (immediate-release); 1-2 h (extended-release) (1) · Antihypertensive effect within 1 week; heart-failure mortality benefit accrues over months of titration (1)
duration:
None (22) · 6 h (immediate-release); ~11 h (extended-release) (1) · ~12 hours (IR); 24 hours (CR) (1)
halflife:
None (22) · 11-13 h (immediate-release); 11-16 h (extended-release) (1) · 7-10 hours'"`UNIQ--ref-0000001B-QINU`"' (1)
bioavailability:
None (22) · 80-90% oral (1) · ~25-35% (extensive first-pass), increased by food which slows absorption and reduces orthostatic risk'"`UNIQ--ref-0000001C-QINU`"' (1)
pregnancy:
None (22) · Category D'"`UNIQ--ref-0000006C-QINU`"' (1) · Limited human data; β-blocker class effects include fetal growth restriction and neonatal bradycardia/hypoglycemia.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
None (22) · Schedule IV (US) (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

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