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Medicines > classes : Botanical or [[:Category:Antidepressants|Antidepressant]] & fda max: 400 mg/day outpatient; 600 mg/day inpatient

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generic:
Trazodone (1)
brand:
Desyrel (original IR), Oleptro (ER), Trittico (1)
classes: (Click arrow to add another value)
mechanism:
'"`UNIQ--vote-0000001B-QINU`"' '''Priapism''' is a recognized rare adverse effect via α1 antagonism in penile vasculature and is the marquee counseling point for male patients'"`UNIQ--ref-0000001C-QINU`"'. (1)
uses:
'"`UNIQ--vote-0000001D-QINU`"', '"`UNIQ--vote-0000001E-QINU`"', '"`UNIQ--vote-0000001F-QINU`"', '"`UNIQ--vote-00000020-QINU`"' (1)
starting dose:
Insomnia (off-label): 25-50 mg PO at bedtime, titrate to effect. Depression: 150 mg/day divided BID-TID; titrate to 400 mg/day outpatient or 600 mg/day inpatient (1)
preparations:
IR tablets 50, 100, 150, 300 mg; Oleptro ER tablets 150, 300 mg (1)
fda max: (Click arrow to add another value)
routes:
Oral (1)
onset:
Sleep effect within 30-60 minutes; antidepressant effect over 1-2 weeks (1)
duration:
~6-8 hours (IR); 24 hours (Oleptro ER) (1)
halflife:
Biphasic: ~3-6 hours alpha, ~5-9 hours beta'"`UNIQ--ref-00000021-QINU`"' (1)
bioavailability:
~65% (oral)'"`UNIQ--ref-00000022-QINU`"' (1)
pregnancy:
Limited human data; observational signals inconclusive.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US. Carries the antidepressant '''Boxed Warning''' for suicidality in children, adolescents, and young adults'"`UNIQ--ref-00000023-QINU`"' (1)

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