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Medicines > classes : Botanical or [[:Category:Antihistamines|First-generation antihistamine (piperazine)]] & onset: ~1 hour

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generic:
Meclizine (1)
brand:
Antivert (Rx), Bonine (OTC), Dramamine Less Drowsy (OTC) (1)
classes: (Click arrow to add another value)
mechanism:
'"`UNIQ--vote-00000013-QINU`"' Anticholinergic burden (dry mouth, blurred vision, urinary retention, cognitive effects) is the principal adverse-event concern and the basis for Beers-list cautions in elderly patients'"`UNIQ--ref-00000014-QINU`"'. (1)
uses:
'"`UNIQ--vote-00000015-QINU`"', '"`UNIQ--vote-00000016-QINU`"', '"`UNIQ--vote-00000017-QINU`"' (1)
starting dose:
Motion sickness: 25-50 mg PO 1 hour before travel, repeat every 24 hours as needed. Vertigo: 25-100 mg/day divided (1)
preparations:
Tablets 12.5, 25 mg; chewable tablets 25 mg (1)
fda max:
100 mg/day (vertigo) (1)
routes:
Oral (1)
onset: (Click arrow to add another value)
duration:
12-24 hours (long for an antihistamine) (1)
halflife:
~6 hours'"`UNIQ--ref-00000018-QINU`"' (1)
bioavailability:
~25% (oral)'"`UNIQ--ref-00000019-QINU`"' (1)
pregnancy:
Older agent with substantial use experience; observational signals reassuring for first-trimester exposure.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Over-the-counter|OTC]] as Bonine and Dramamine Less Drowsy; [[USLegal:Prescription only|Rx-only]] as Antivert (1)

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