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Medicines > classes : Botanical or Classic Psychedelic or [[:Category:Analgesics|Non-opioid analgesic]]

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generic:
brand:
None (85) · Delysid (historical, Sandoz, withdrawn 1965) (1) · Tylenol, Panadol (international), Ofirmev (IV); huge OTC presence (1)
classes: (Click arrow to add another value)
mechanism:
5-HT2A agonist (26) · Potent 5-HT2A agonist (5) · LSD analogue; 5-HT2A agonist (4) · Prodrug of LSD; 5-HT2A agonist (4) · Contains LSA (2) · Contains mescaline (2)
uses:
None (86) · '"`UNIQ--vote-000006A2-QINU`"', '"`UNIQ--vote-000006A3-QINU`"', '"`UNIQ--vote-000006A4-QINU`"' (1)
starting dose:
None (86) · 325-1000 mg PO every 4-6 hours as needed; maximum 4 g/d in healthy adults, 3 g/d in regular users or hepatic risk; pediatric 10-15 mg/kg every 4-6 hours (1)
preparations:
None (86) · 325, 500, 650 mg tablets; 80, 160 mg chewables; 160 mg/5 mL pediatric liquid; 325 mg suppository; 1000 mg/100 mL IV (Ofirmev); fixed-dose combinations with opioids, decongestants, antihistamines (1)
fda max:
None (86) · 4 g/d in healthy adults; 3 g/d conservative limit; 2 g/d in cirrhosis or chronic alcohol use (1)
routes:
None (85) · IV (1) · Oral (2) · rectal (1)
onset:
None (85) · 30–60 minutes (1) · PO: 30-60 minutes; IV: minutes (1)
duration:
None (85) · 4-6 hours (1) · 8–12 hours (1)
halflife:
None (85) · 1-3 hours (normal liver); markedly prolonged in overdose with glutathione depletion'"`UNIQ--ref-000006A5-QINU`"' (1) · 3–5 hours (1)
bioavailability:
None (85) · 70–90% (oral) (1) · ~85-98% (oral)'"`UNIQ--ref-000006A6-QINU`"' (1)
pregnancy:
None (85) · Long the preferred analgesic-antipyretic in pregnancy; recent observational studies have raised speculative neurodevelopmental signals that remain under investigation.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1) · Not established (1)
legal:
None (85) · OTC and [[USLegal:Prescription only|Rx-only]] (IV, combination products) in US (1) · Schedule I (United States) (1)

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