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Medicines > classes : Botanical or Classic Psychedelic or [[:Category:Antioxidants|Antioxidant]]

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generic:
brand:
None (85) · Delysid (historical, Sandoz, withdrawn 1965) (1) · Generic; huge OTC presence (1) · Generic; many OTC formulations (1)
classes: (Click arrow to add another value)
mechanism:
5-HT2A agonist (26) · Potent 5-HT2A agonist (5) · LSD analogue; 5-HT2A agonist (4) · Prodrug of LSD; 5-HT2A agonist (4) · None (2) · Contains LSA (2) · Contains mescaline (2)
uses:
None (86) · '"`UNIQ--vote-000012CE-QINU`"', '"`UNIQ--vote-000012CF-QINU`"', '"`UNIQ--vote-000012D0-QINU`"' (1) · '"`UNIQ--vote-000012E5-QINU`"', '"`UNIQ--vote-000012E6-QINU`"', '"`UNIQ--vote-000012E7-QINU`"', '"`UNIQ--vote-000012E8-QINU`"' (1)
starting dose:
None (86) · General supplementation 75-90 mg/d (RDA); scurvy treatment 100-1000 mg/d for several weeks; megadose claims unsupported (1) · Replacement: 15-30 mg (22.5-45 IU) daily; NASH: 800 IU daily; AREDS-2: 400 IU daily (in combination formula) (1)
preparations:
None (86) · 100, 200, 400 IU softgels and capsules; many proprietary OTC blends; combined formulations (AREDS-2) (1) · 100, 250, 500, 1000 mg tablets, chewables, gummies, effervescent; IV (specialty) (1)
fda max:
None (86) · UL 1000 mg (~1500 IU natural)/d in adults; routinely exceeded in older AREDS-1 trials (1) · UL 2000 mg/d in adults (1)
routes:
None (85) · IV (1) · Oral (3)
onset:
None (85) · 30–60 minutes (1) · Days for symptom improvement in scurvy (1) · Days to weeks for tissue saturation (1)
duration:
None (85) · 8–12 hours (1) · Hours (1) · Weeks (fat-soluble) (1)
halflife:
None (85) · 3–5 hours (1) · ~10-20 days (steady-state body pool); single dose plasma ~2 hours (1) · ~3-4 days plasma; adipose tissue stores last months (1)
bioavailability:
None (85) · 70–90% (oral) (1) · High with fat-containing meal; reduced in malabsorption (1) · ~70-90% at typical doses; saturable at high doses (>500 mg) (1)
pregnancy:
None (85) · Not established (1) · Safe at replacement doses; high-dose use generally avoided.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1) · Safe at routine doses; routinely supplemented in pregnancy.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
None (85) · OTC in US (2) · Schedule I (United States) (1)

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