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Medicines > classes : Botanical or Classic Psychedelic or [[:Category:NRIs|Selective norepinephrine reuptake inhibitor (NRI)]]

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generic:
brand:
None (85) · Delysid (historical, Sandoz, withdrawn 1965) (1) · Strattera (1)
classes: (Click arrow to add another value)
mechanism:
5-HT2A agonist (26) · Potent 5-HT2A agonist (5) · LSD analogue; 5-HT2A agonist (4) · Prodrug of LSD; 5-HT2A agonist (4) · Contains LSA (2) · Contains mescaline (2)
uses:
None (86) · '"`UNIQ--vote-00000013-QINU`"' (1)
starting dose:
None (86) · Children ≤70 kg: 0.5 mg/kg/day, titrate to 1.2 mg/kg/day after 3 days. Adults and children >70 kg: 40 mg PO once daily for 3 days, then 80 mg/day, then if needed 100 mg/day after 2-4 weeks (1)
preparations:
None (86) · Capsules 10, 18, 25, 40, 60, 80, 100 mg (1)
fda max:
None (86) · 100 mg/day (adult); 1.4 mg/kg/day or 100 mg total (pediatric, whichever lower) (1)
routes:
None (85) · Oral (2)
onset:
None (85) · 30–60 minutes (1) · ADHD effect emerges over 1-2 weeks (slower than psychostimulants); full effect 4-6 weeks (1)
duration:
None (85) · 24 hours (once-daily or split BID dosing) (1) · 8–12 hours (1)
halflife:
None (85) · 3–5 hours (1) · ~5 hours in extensive CYP2D6 metabolizers; ~21 hours in CYP2D6 poor metabolizers'"`UNIQ--ref-00000014-QINU`"' (1)
bioavailability:
None (85) · 70–90% (oral) (1) · ~63% (oral; extensive first-pass)'"`UNIQ--ref-00000015-QINU`"' (1)
pregnancy:
None (85) · Limited human data.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1) · Not established (1)
legal:
None (85) · Schedule I (United States) (1) · [[USLegal:Prescription only|Rx-only]] in US. '''Not a controlled substance''', the principal clinical selling point versus psychostimulant ADHD options. Carries the antidepressant-class '''Boxed Warning''' for suicidal ideation in pediatric patients'"`UNIQ--ref-00000016-QINU`"' (1)

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