Drilldown: Medicines

None (2)

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None (85) · Delysid (historical, Sandoz, withdrawn 1965) (1) · Zulresso (1) · Zurzuvae (1)

Research material · Classic Psychedelic · Stimulant · Opioid · Sedative-Hypnotic · Phenethylamine · Tryptamine · Benzodiazepine · Botanical · [[:Category:Antihypertensives|Antihypertensive]] · Dissociative · Anticonvulsant · Antidepressant · Plant Medicine · Analgesic · Antipsychotic · Antiparkinsonian · Empathogen · Neuroleptic · Cathinone

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5-HT2A agonist (26) · Potent 5-HT2A agonist (5) · LSD analogue; 5-HT2A agonist (4) · Prodrug of LSD; 5-HT2A agonist (4) · Contains LSA (2) · Contains mescaline (2)

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None (86) · Postpartum depression (PPD) in adults (1) · Postpartum depression (PPD) in adults (FDA-approved 2023) (1)

None (86) · 50 mg PO once daily with fatty food in the evening × 14 days (1) · Single 60-hour continuous IV infusion: 30 mcg/kg/h × 4h → 60 mcg/kg/h × 20h → 90 mcg/kg/h × 28h → 60 mcg/kg/h × 4h → 30 mcg/kg/h × 4h (1)

None (86) · 100 mg/20 mL vial, single-use (1) · 20 mg, 25 mg, 30 mg capsules (1)

None (86) · 50 mg/d × 14 d (1) · Single 60-hour course (1)

None (85) · Intravenous (continuous infusion in a REMS-certified facility) (1) · Oral (2)

None (85) · 30–60 minutes (1) · Antidepressant effect within hours of infusion start; sustained at 30 days (1) · Day 3 of dosing in trials; sustained through day 45 (1)

None (85) · 14-day course; effect persists after discontinuation in trials (1) · 8–12 hours (1) · Single infusion course (1)

None (85) · 3–5 hours (1) · ~16-23 hours (1) · ~9 hours (terminal) (1)

None (85) · 100% (IV) (1) · 70–90% (oral) (1) · Adequate (food-dependent, must take with fatty meal) (1)

None (85) · Limited data; avoid in pregnancy. Lactation: present in milk; consider risks (1) · Medicine is structurally identical to endogenous allopregnanolone; pregnancy considerations relate to breastfeeding during/after infusion. Limited data; brief interruption of breastfeeding considered (1) · Not established (1)

None (85) · Rx, Schedule IV (US) (1) · Rx; REMS program required (excessive sedation/loss of consciousness during infusion) (1) · Schedule I (United States) (1)