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Medicines > classes : Botanical or Classic Psychedelic or Selective 5HT2A inverse agonist (with weaker 5HT2C inverse agonism)

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generic:
brand:
None (85) · Delysid (historical, Sandoz, withdrawn 1965) (1) · Nuplazid (1)
classes: (Click arrow to add another value)
mechanism:
5-HT2A agonist (26) · Potent 5-HT2A agonist (5) · LSD analogue; 5-HT2A agonist (4) · Prodrug of LSD; 5-HT2A agonist (4) · Contains LSA (2) · Contains mescaline (2)
uses:
None (86) · Hallucinations and delusions associated with Parkinson's disease psychosis (PDP). Investigational for psychosis in other dementias and as augmentation for depression. (1)
starting dose:
None (86) · 34 mg PO once daily (1)
preparations:
None (86) · 10 mg, 34 mg capsules/tablets (1)
fda max:
None (86) · 34 mg/d (1)
routes:
None (85) · Oral (2)
onset:
None (85) · 30–60 minutes (1) · Benefit over weeks of dosing (1)
duration:
None (85) · 8–12 hours (1) · Daily dosing (1)
halflife:
None (85) · 3–5 hours (1) · ~57 hours (parent), ~200 h (active metabolite) (1)
bioavailability:
None (85) · 70–90% (oral) (1) · Not characterized; oral dosing once daily (1)
pregnancy:
None (85) · Limited data; avoid (1) · Not established (1)
legal:
None (85) · Rx. FDA black-box warning for increased mortality in elderly patients with dementia-related psychosis (class warning shared with all antipsychotics) (1) · Schedule I (United States) (1)

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