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Medicines > classes : Botanical or Classic Psychedelic or Selective norepinephrine reuptake inhibitor (NRI) with 5HT1A partial agonism

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generic:
brand:
None (85) · Delysid (historical, Sandoz, withdrawn 1965) (1) · Qelbree (1)
classes: (Click arrow to add another value)
mechanism:
5-HT2A agonist (26) · Potent 5-HT2A agonist (5) · LSD analogue; 5-HT2A agonist (4) · Prodrug of LSD; 5-HT2A agonist (4) · Contains LSA (2) · Contains mescaline (2)
uses:
None (86) · ADHD in children (6+), adolescents, and adults (FDA-approved 2021 for pediatric, 2022 for adult) (1)
starting dose:
None (86) · Pediatric 6-11: 100 mg PO daily, titrate weekly to max 400 mg. Adolescent 12-17: 200 mg, max 400 mg. Adult: 200 mg, max 600 mg. (1)
preparations:
None (86) · 100 mg, 150 mg, 200 mg extended-release capsules (can be sprinkled on food) (1)
fda max:
None (86) · 400 mg/d (pediatric); 600 mg/d (adult) (1)
routes:
None (85) · Oral (2)
onset:
None (85) · 30–60 minutes (1) · ADHD symptom improvement reported within 1-2 weeks (faster than atomoxetine which takes 4-6 weeks) (1)
duration:
None (85) · 8–12 hours (1) · Daily dosing (1)
halflife:
None (85) · 3–5 hours (1) · ~7 hours (1)
bioavailability:
None (85) · 70–90% (oral) (1) · Adequate oral bioavailability with extended-release formulation (1)
pregnancy:
None (85) · Limited data (1) · Not established (1)
legal:
None (85) · Rx, '''not a controlled substance''' (no DEA scheduling) (1) · Schedule I (United States) (1)

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