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Medicines > classes : Botanical or Stimulant or wake-promoting agent

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generic:
None (2)
brand:
None (65) · Benzedrex (1) · Sunosi (1) · Wakix (1)
classes: (Click arrow to add another value)
mechanism:
Monoamine releasing agent (8) · Dopamine/norepinephrine reuptake inhibitor (5) · Cathinone analogue; monoamine reuptake inhibitor (2) · Contains LSA (2) · Contains mescaline (2) · Dopamine and norepinephrine reuptake inhibitor (2) · Norepinephrine–dopamine reuptake inhibitor (2)
uses:
None (66) · Excessive daytime sleepiness in adults with narcolepsy or obstructive sleep apnea (OSA) (1) · Excessive daytime sleepiness or cataplexy in adults with narcolepsy (FDA-approved August 2019) (1)
starting dose:
None (66) · Narcolepsy: 75 mg PO once daily upon awakening, titrate every 3 days. OSA: 37.5 mg PO once daily, titrate. (1) · Week 1: 8.9 mg PO once daily in the morning. Week 2: 17.8 mg. Week 3+: 35.6 mg (max). Titrate as needed. (1)
preparations:
None (66) · 4.45 mg, 17.8 mg tablets (1) · 75 mg, 150 mg tablets (1)
fda max:
None (66) · 150 mg/d (1) · 35.6 mg/d (1)
routes:
None (66) · Oral (2)
onset:
None (66) · Wake-promoting effect over weeks of titration (1) · ~30-60 min (1)
duration:
None (66) · Daily morning dosing (1) · ~9 hours (1)
halflife:
None (66) · ~20 hours (1) · ~7.1 hours (1)
bioavailability:
None (66) · Not formally established; oral once-daily adequate (1) · ~95% (1)
pregnancy:
None (66) · Limited data; pitolisant may reduce hormonal contraceptive efficacy (1) · Limited data; pregnancy exposure registry available (1)
legal:
None (66) · Rx, '''not a controlled substance''' (unique among wake-promoting agents) (1) · Rx, Schedule IV (US) (1)

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