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Drilldown: Medicines

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Medicines > classes : Cannabinoid or Empathogen or Sedative-hypnotic

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generic:
brand:
None (30) · (none, never marketed) (1) · Cesamet (1) · Dalmane (1) · Doral (1) · Doriden (1) · Epidiolex (1) · Halcion (1) · Hetlioz (1) · Imovane (1) · Lunesta (1) · Marinol (1) · Mogadon (1) · Nembutal (1) · Placidyl (1) · ProSom (1) · Quaalude (1) · Restoril (1) · Rohypnol (1) · Rozerem (1) · Sativex (1) · Seconal (1) · Sonata (1) · THIP (1) · Versed (1) · Xyrem (1)
classes: (Click arrow to add another value)
mechanism:
None (2) · CB1 partial agonist (1) · CB1 partial agonist (lower potency than delta-9) (1) · CB1/CB2 agonist (higher potency than THC) (1) · CB1/CB2 partial agonist (1) · Extremely potent GABAA positive allosteric modulator (1) · GABAA positive allosteric modulator (15) · GABAA positive allosteric modulator (non-benzodiazepine) (3) · GABAA positive allosteric modulator; very long half-life (1) · GABAA potentiator (1) · GABAA potentiator and direct activator (2) · GABAB agonist; GHB receptor agonist (1) · MAO inhibitor; monoamine releasing agent (1) · MAO inhibitor; serotonin releasing agent (1) · Melatonin receptor agonist (2) · Monoamine releasing agent (3) · Monoamine releasing agent; 5-HT2A agonist (1) · Monoamine releasing agent; serotonergic at higher doses (1) · Multiple mechanisms; GPR55 antagonist; TRPV1 agonist (1) · Positive allosteric modulator of the GABA<sub>A</sub> receptor at the benzodiazepine binding site; increases frequency of Cl<sup>−</sup> channel opening, producing anxiolytic, sedative, hypnotic, anticonvulsant, and skeletal-muscle relaxant effects. (1) · Selective GABAA agonist (extrasynaptic delta subunit) (1) · Semi-synthetic; CB1 agonist (1) · Serotonin releasing agent (2) · Serotonin releasing agent; 5-HT2A agonist (3) · Serotonin/dopamine/norepinephrine releasing agent; 5-HT2A agonist (1) · Serotonin/norepinephrine/dopamine releasing agent (3) · Synthetic cannabinoid; CB1/CB2 agonist (1) · Synthetic THC; CB1/CB2 agonist (1) · THC + CBD; CB1/CB2 agonist (1)
uses:
None (54) · No approved medical problem. Encountered as a designer/research benzodiazepine and, increasingly, as an adulterant in illicit opioid supplies. (1)
starting dose:
None (54) · No medical dose. Active recreational doses reported in the 0.5–1.5 mg range (similar potency to alprazolam). (1)
preparations:
None (54) · Illicit tablets ("bars"), powders, blotter, occasionally solutions. No pharmaceutical product exists. (1)
fda max:
None (54) · N/A (never approved) (1)
routes:
None (54) · intranasal; rectal and IV reported. (1) · Oral (1) · sublingual (1)
onset:
None (54) · ~20–40 min PO; faster sublingual/intranasal. (1)
duration:
None (54) · 6–10 h subjective; full pharmacologic effect considerably longer. (1)
halflife:
None (54) · Estimated ~12–17 h (some sources cite up to ~21 h); active metabolites prolong effect. (1)
bioavailability:
None (54) · Not formally characterized in humans. (1)
pregnancy:
None (54) · Avoid. Benzodiazepines are associated with neonatal sedation, floppy-infant syndrome, and withdrawal; teratogenic signal weak but non-zero. Designer benzo with no safety data, assume worst-case. (1)
legal:
None (55)

Showing below up to 55 results in range #1 to #55.

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