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Medicines > classes : Cathinone or [[:Category:Antithyroid_agents|Antithyroid agent]]

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generic:
3-MMC (1) · Butylone (1) · Cathinone (1) · Ephylone (1) · Ethcathinone (1) · Ethylone (1) · Hexedrone (1) · Mephedrone (1) · Methcathinone (1) · Methimazole (thiamazole) (1) · Methylone (1) · Mexedrone (1) · N-Ethylhexedrone (1) · N-Ethylpentedrone (1) · Pentedrone (1)
brand:
None (14) · Tapazole; outside US Mercazole (1)
classes: (Click arrow to add another value)
mechanism:
Cathinone analogue; monoamine reuptake inhibitor (2) · Monoamine releasing agent (4) · Monoamine releasing agent; active ingredient in khat (1) · Norepinephrine and dopamine releasing agent (1) · Norepinephrine/dopamine releasing agent (1) · Norepinephrine/dopamine reuptake inhibitor (1) · Serotonin releasing agent; monoamine reuptake inhibitor (1) · Serotonin/norepinephrine/dopamine releasing agent (3) · '"`UNIQ--vote-00000ECD-QINU`"' Agranulocytosis is the most-feared adverse effect (~0.3%, usually first 90 days of treatment; warn patients to seek urgent CBC for fever or severe sore throat). Hepatotoxicity is class-recognized but more often associated with PTU'"`UNIQ--ref-00000ECE-QINU`"'. (1)
uses:
None (14) · '"`UNIQ--vote-00000ECF-QINU`"', '"`UNIQ--vote-00000ED0-QINU`"', '"`UNIQ--vote-00000ED1-QINU`"', '"`UNIQ--vote-00000ED2-QINU`"' (1)
starting dose:
None (14) · 10-40 mg PO daily depending on hyperthyroidism severity; titrate by clinical and biochemical response (target TSH/free T4) (1)
preparations:
None (14) · 5, 10 mg tablets (1)
fda max:
None (14) · 60 mg/d typical (1)
routes:
None (14) · Oral (1)
onset:
None (14) · Biochemical improvement within 2-4 weeks; full euthyroid state 6-12 weeks (1)
duration:
None (14) · 24 hours (1)
halflife:
None (14) · ~4-6 hours (plasma); intrathyroidal accumulation gives a much longer functional duration'"`UNIQ--ref-00000ED3-QINU`"' (1)
bioavailability:
None (14) · ~93% (oral)'"`UNIQ--ref-00000ED4-QINU`"' (1)
pregnancy:
None (15)
legal:
None (14) · [[USLegal:Prescription only|Rx-only]] in US (1)

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