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Medicines > classes : Cathinone or [[:Category:Beta blockers|Combined alpha-1 and non-selective beta blocker]]

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generic:
3-MMC (1) · Butylone (1) · Cathinone (1) · Ephylone (1) · Ethcathinone (1) · Ethylone (1) · Hexedrone (1) · Labetalol (1) · Mephedrone (1) · Methcathinone (1) · Methylone (1) · Mexedrone (1) · N-Ethylhexedrone (1) · N-Ethylpentedrone (1) · Pentedrone (1)
brand:
None (14) · Trandate, Normodyne (discontinued in US) (1)
classes: (Click arrow to add another value)
mechanism:
Cathinone analogue; monoamine reuptake inhibitor (2) · Monoamine releasing agent (4) · Monoamine releasing agent; active ingredient in khat (1) · Norepinephrine and dopamine releasing agent (1) · Norepinephrine/dopamine releasing agent (1) · Norepinephrine/dopamine reuptake inhibitor (1) · Serotonin releasing agent; monoamine reuptake inhibitor (1) · Serotonin/norepinephrine/dopamine releasing agent (3) · '"`UNIQ--vote-00000015-QINU`"' The favorable pregnancy safety profile and the dual mechanism support its first-line role in pregnancy-associated hypertension and in hypertensive emergencies where rapid, controllable BP reduction is needed'"`UNIQ--ref-00000016-QINU`"'. (1)
uses:
None (14) · '"`UNIQ--vote-00000017-QINU`"', '"`UNIQ--vote-00000018-QINU`"', '"`UNIQ--vote-00000019-QINU`"' (1)
starting dose:
None (14) · Oral: 100 mg PO BID, titrate to 400 mg BID. IV: 20 mg over 2 minutes, repeat 40-80 mg every 10 minutes as needed (maximum cumulative 300 mg); continuous infusion 2 mg/minute (1)
preparations:
None (14) · Tablets 100, 200, 300 mg; injection 5 mg/mL (1)
fda max:
None (14) · 2400 mg/day (oral); 300 mg total per IV bolus dosing series (1)
routes:
None (14) · intravenous (1) · Oral (1)
onset:
None (14) · BP effect within hours (oral); 5-10 minutes (IV) (1)
duration:
None (14) · 8-12 hours (oral); 4-6 hours (IV) (1)
halflife:
None (14) · ~6-8 hours'"`UNIQ--ref-0000001A-QINU`"' (1)
bioavailability:
None (14) · ~25% (oral; extensive first-pass)'"`UNIQ--ref-0000001B-QINU`"' (1)
pregnancy:
None (14) · '''Among the safest antihypertensives in pregnancy''', recommended for chronic hypertension during pregnancy and first-line for severe hypertension in preeclampsia and eclampsia'"`UNIQ--ref-0000001C-QINU`"' (1)
legal:
None (14) · [[USLegal:Prescription only|Rx-only]] in US (1)

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