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Drilldown: Medicines

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Medicines > classes : Cathinone or [[:Category:Biguanides|Biguanide]]

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generic:
3-MMC (1) · Butylone (1) · Cathinone (1) · Ephylone (1) · Ethcathinone (1) · Ethylone (1) · Hexedrone (1) · Mephedrone (1) · Metformin (1) · Methcathinone (1) · Methylone (1) · Mexedrone (1) · N-Ethylhexedrone (1) · N-Ethylpentedrone (1) · Pentedrone (1)
brand:
None (14) · Glucophage, Glucophage XR, Fortamet, Glumetza, Riomet (1)
classes: (Click arrow to add another value)
mechanism:
Cathinone analogue; monoamine reuptake inhibitor (2) · Monoamine releasing agent (4) · Monoamine releasing agent; active ingredient in khat (1) · Norepinephrine and dopamine releasing agent (1) · Norepinephrine/dopamine releasing agent (1) · Norepinephrine/dopamine reuptake inhibitor (1) · Serotonin releasing agent; monoamine reuptake inhibitor (1) · Serotonin/norepinephrine/dopamine releasing agent (3) · '"`UNIQ--vote-00000013-QINU`"' Does not stimulate insulin secretion; minimal hypoglycemia risk as monotherapy. Cleared renally unchanged; dose-adjust by eGFR'"`UNIQ--ref-00000014-QINU`"'. Rare lactic acidosis primarily in renal failure or acute illness. (1)
uses:
None (14) · '"`UNIQ--vote-00000015-QINU`"', '"`UNIQ--vote-00000016-QINU`"', '"`UNIQ--vote-00000017-QINU`"' (1)
starting dose:
None (14) · 500 mg PO once or twice daily with meals; titrate weekly to limit GI effects (1)
preparations:
None (14) · 500 mg, 850 mg, 1000 mg IR tablets; 500 mg, 750 mg, 1000 mg ER tablets; 500 mg/5 mL oral solution (1)
fda max:
None (14) · 2550 mg/d (IR); 2000 mg/d (ER) (1)
routes:
None (14) · Oral (1)
onset:
None (14) · Glucose lowering within days; HbA1c effect at 8-12 weeks (1)
duration:
None (14) · ~12 hours (IR); 24 hours (ER) (1)
halflife:
None (14) · 6.2 hours (plasma); ~17 hours in erythrocytes'"`UNIQ--ref-00000018-QINU`"' (1)
bioavailability:
None (14) · 50-60% (oral; decreased with food, but food given anyway for GI tolerance)'"`UNIQ--ref-00000019-QINU`"' (1)
pregnancy:
None (14) · Generally considered safe; widely used in PCOS and gestational diabetes; placental transfer occurs.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
None (14) · [[USLegal:Prescription only|Rx-only]] in US (1)

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