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Medicines > classes : Cathinone or [[:Category:Sulfonylureas|Sulfonylurea (second-generation)]]

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generic:
3-MMC (1) · Butylone (1) · Cathinone (1) · Ephylone (1) · Ethcathinone (1) · Ethylone (1) · Glipizide (1) · Hexedrone (1) · Mephedrone (1) · Methcathinone (1) · Methylone (1) · Mexedrone (1) · N-Ethylhexedrone (1) · N-Ethylpentedrone (1) · Pentedrone (1)
brand:
None (14) · Glucotrol, Glucotrol XL (1)
classes: (Click arrow to add another value)
mechanism:
Cathinone analogue; monoamine reuptake inhibitor (2) · Monoamine releasing agent (4) · Monoamine releasing agent; active ingredient in khat (1) · Norepinephrine and dopamine releasing agent (1) · Norepinephrine/dopamine releasing agent (1) · Norepinephrine/dopamine reuptake inhibitor (1) · Serotonin releasing agent; monoamine reuptake inhibitor (1) · Serotonin/norepinephrine/dopamine releasing agent (3) · '"`UNIQ--vote-000002D7-QINU`"' Hypoglycemia is the central risk, especially in elderly and renally impaired patients (glipizide has shorter half-life than glyburide, which is one reason it is preferred in older adults). CYP2C9 substrate; weight gain typical. (1)
uses:
None (14) · '"`UNIQ--vote-000002D8-QINU`"' (1)
starting dose:
None (14) · 5 mg PO once daily, 30 minutes before breakfast; XL: 5 mg with breakfast (1)
preparations:
None (14) · 5 mg, 10 mg immediate-release tablets; 2.5 mg, 5 mg, 10 mg extended-release tablets (1)
fda max:
None (14) · 40 mg/d (IR; doses >15 mg given as divided BID); 20 mg/d (XL) (1)
routes:
None (14) · Oral (1)
onset:
None (14) · Within 30 minutes (IR) (1)
duration:
None (14) · ~12-24 hours (1)
halflife:
None (14) · 2-5 hours'"`UNIQ--ref-000002D9-QINU`"' (1)
bioavailability:
None (14) · ~100% (oral; food delays absorption, hence pre-meal dosing for IR)'"`UNIQ--ref-000002DA-QINU`"' (1)
pregnancy:
None (14) · Avoid; switch to insulin. Hypoglycemia in newborn reported.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
None (14) · [[USLegal:Prescription only|Rx-only]] in US (1)

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