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Drilldown: Medicines

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Medicines > classes : Cathinone or [[:Category:Tryptamines|Tryptamine]]

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generic:
3-MMC (1) · Butylone (1) · Cathinone (1) · DMT (1) · Ephylone (1) · Ethcathinone (1) · Ethylone (1) · Hexedrone (1) · Mephedrone (1) · Methcathinone (1) · Methylone (1) · Mexedrone (1) · N-Ethylhexedrone (1) · N-Ethylpentedrone (1) · Pentedrone (1) · Psilocybin (1)
brand:
None (15) · COMP360 (Compass Pathways, investigational synthesized clinical formulation) (1)
classes: (Click arrow to add another value)
mechanism:
5-HT2A partial agonist; sigma-1 agonist (1) · Cathinone analogue; monoamine reuptake inhibitor (2) · Monoamine releasing agent (4) · Monoamine releasing agent; active ingredient in khat (1) · Norepinephrine and dopamine releasing agent (1) · Norepinephrine/dopamine releasing agent (1) · Norepinephrine/dopamine reuptake inhibitor (1) · Prodrug to [[Psilocin|psilocin]] (4-hydroxy-N,N-dimethyltryptamine), a partial agonist at the [[Receptor:5-HT2A|5-HT2A]] serotonin receptor; the action that defines the classical-psychedelic mechanism (1) · Serotonin releasing agent; monoamine reuptake inhibitor (1) · Serotonin/norepinephrine/dopamine releasing agent (3)
uses:
None (15) · (investigational) '"`UNIQ--vote-000000EF-QINU`"', '"`UNIQ--vote-000000F0-QINU`"', '"`UNIQ--vote-000000F1-QINU`"', '"`UNIQ--vote-000000F2-QINU`"', '"`UNIQ--vote-000000F3-QINU`"' (1)
starting dose:
None (15) · Modern clinical-trial standard: 25 mg synthesized psilocybin, single oral dose with psychological support (1)
preparations:
None (15) · Synthesized psilocybin capsules (COMP360 and other investigational formulations); dried whole [[Psilocybe|Psilocybe]] mushrooms (variable potency, no legal supply chain in most jurisdictions); psilocybin truffles (Psilocybe sclerotia, legal in the Netherlands) (1)
fda max:
None (15) · Not FDA-approved; clinical-trial protocols use up to 30 mg in adult investigational dosing (1)
routes:
None (15) · Oral (1)
onset:
None (15) · 20-45 min subjective onset; psilocin formation from psilocybin requires intestinal and hepatic alkaline phosphatase (1)
duration:
None (14) · 4-6 hours (1) · About 20 minutes (1)
halflife:
None (14) · 9–12 minutes (intravenous) (1) · Psilocin: ~2-3 h; psilocybin itself is a prodrug, dephosphorylated within minutes of absorption (1)
bioavailability:
None (15) · Oral bioavailability of psilocin from administered psilocybin approximately 50% (1)
pregnancy:
None (15) · Not studied in human pregnancy; no approved clinical use in any population (1)
legal:
None (15) · [[USLegal:DEA Schedule I|Schedule I]] (United States) (1)

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