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Drilldown: Medicines

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Medicines > classes : Cathinone or Combined cholinesterase inhibitor + NMDA antagonist

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generic:
3-MMC (1) · Butylone (1) · Cathinone (1) · Ephylone (1) · Ethcathinone (1) · Ethylone (1) · Hexedrone (1) · Memantine ER / Donepezil (1) · Mephedrone (1) · Methcathinone (1) · Methylone (1) · Mexedrone (1) · N-Ethylhexedrone (1) · N-Ethylpentedrone (1) · Pentedrone (1)
brand:
None (14) · Namzaric (1)
classes: (Click arrow to add another value)
mechanism:
Cathinone analogue; monoamine reuptake inhibitor (2) · Donepezil: reversible AChE inhibitor, increases synaptic acetylcholine. Memantine: uncompetitive low-affinity NMDA receptor antagonist, dampens pathological glutamate overactivation while preserving normal synaptic signaling. Targets two distinct mechanisms in Alzheimer's. (1) · Monoamine releasing agent (4) · Monoamine releasing agent; active ingredient in khat (1) · Norepinephrine and dopamine releasing agent (1) · Norepinephrine/dopamine releasing agent (1) · Norepinephrine/dopamine reuptake inhibitor (1) · Serotonin releasing agent; monoamine reuptake inhibitor (1) · Serotonin/norepinephrine/dopamine releasing agent (3)
uses:
None (14) · '"`UNIQ--vote-00000468-QINU`"' (1)
starting dose:
None (14) · For patients already stable on memantine 28 mg/d + donepezil 10 mg/d, switch to one capsule daily of equivalent strength (1)
preparations:
None (14) · 7/10, 14/10, 21/10, 28/10 mg ER capsules (memantine ER / donepezil) (1)
fda max:
None (14) · 28/10 mg/d (1)
routes:
None (14) · Oral (capsule whole or opened/sprinkled on applesauce) (1)
onset:
None (14) · Component effects accumulate over weeks (1)
duration:
None (14) · 24 h (1)
halflife:
None (14) · ~60–80 h (memantine); ~70 h (donepezil) (1)
bioavailability:
None (14) · ~100% both components (1)
pregnancy:
None (14) · Not relevant (geriatric problem) (1)
legal:
None (14) · Rx-only in US (1)

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