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Drilldown: Medicines

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Medicines > classes : Cathinone or non-stimulant ADHD agent

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generic:
None (1) · 3-MMC (1) · Butylone (1) · Cathinone (1) · Ephylone (1) · Ethcathinone (1) · Ethylone (1) · Hexedrone (1) · Mephedrone (1) · Methcathinone (1) · Methylone (1) · Mexedrone (1) · N-Ethylhexedrone (1) · N-Ethylpentedrone (1) · Pentedrone (1)
brand:
None (14) · Qelbree (1)
classes: (Click arrow to add another value)
mechanism:
Cathinone analogue; monoamine reuptake inhibitor (2) · Monoamine releasing agent (4) · Monoamine releasing agent; active ingredient in khat (1) · Norepinephrine and dopamine releasing agent (1) · Norepinephrine/dopamine releasing agent (1) · Norepinephrine/dopamine reuptake inhibitor (1) · Selective NET inhibitor (no significant DAT activity, distinguishes from amphetamine/methylphenidate). Also: 5HT1A receptor partial agonism, 5HT2B and 5HT7 receptor antagonism. The serotonergic actions may underlie better tolerability and possibly different efficacy spectrum than atomoxetine. (1) · Serotonin releasing agent; monoamine reuptake inhibitor (1) · Serotonin/norepinephrine/dopamine releasing agent (3)
uses:
None (14) · ADHD in children (6+), adolescents, and adults (FDA-approved 2021 for pediatric, 2022 for adult) (1)
starting dose:
None (14) · Pediatric 6-11: 100 mg PO daily, titrate weekly to max 400 mg. Adolescent 12-17: 200 mg, max 400 mg. Adult: 200 mg, max 600 mg. (1)
preparations:
None (14) · 100 mg, 150 mg, 200 mg extended-release capsules (can be sprinkled on food) (1)
fda max:
None (14) · 400 mg/d (pediatric); 600 mg/d (adult) (1)
routes:
None (14) · Oral (1)
onset:
None (14) · ADHD symptom improvement reported within 1-2 weeks (faster than atomoxetine which takes 4-6 weeks) (1)
duration:
None (14) · Daily dosing (1)
halflife:
None (14) · ~7 hours (1)
bioavailability:
None (14) · Adequate oral bioavailability with extended-release formulation (1)
pregnancy:
None (14) · Limited data (1)
legal:
None (14) · Rx, '''not a controlled substance''' (no DEA scheduling) (1)

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