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Medicines > classes : Classic Psychedelic or [[:Category:DOACs|Direct oral anticoagulant (DOAC)]] & fda max: 30 mg/d (acute VTE first 21 days as 15 mg BID); otherwise 20 mg/d

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generic:
Rivaroxaban (1)
brand:
Xarelto (1)
classes: (Click arrow to add another value)
mechanism:
'"`UNIQ--vote-0000050D-QINU`"' CYP3A4 (primary) and P-glycoprotein substrate; strong dual inhibitors or inducers materially shift exposure. Reversal: andexanet alfa for life-threatening bleeding; 4F-PCC commonly used off-label when andexanet unavailable'"`UNIQ--ref-0000050E-QINU`"'. (1)
uses:
'"`UNIQ--vote-0000050F-QINU`"', '"`UNIQ--vote-00000510-QINU`"', '"`UNIQ--vote-00000511-QINU`"', '"`UNIQ--vote-00000512-QINU`"' (1)
starting dose:
NVAF: 20 mg PO once daily with the evening meal (15 mg if CrCl 15-50); acute VTE: 15 mg BID for 21 days, then 20 mg daily; CAD/PAD: 2.5 mg BID with aspirin (1)
preparations:
2.5, 10, 15, 20 mg tablets (1)
fda max: (Click arrow to add another value)
routes:
Oral (1)
onset:
Peak anticoagulant effect 2-4 hours (1)
duration:
24 hours (1)
halflife:
5-9 hours (elderly: 11-13 hours)'"`UNIQ--ref-00000513-QINU`"' (1)
bioavailability:
~80-100% with food at 15-20 mg doses (10 mg dose: ~80% without food); '''must be taken with food''' at therapeutic doses'"`UNIQ--ref-00000514-QINU`"' (1)
pregnancy:
Avoid in pregnancy; switch to LMWH. Crosses placenta; warfarin-class concerns about fetal hemorrhage and teratogenicity make heparins the preferred class.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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