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Medicines > classes : Classic Psychedelic or [[:Category:Psychostimulants|Psychostimulant]] & routes: Oral

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generic:
Lisdexamfetamine (dimesylate) (1) · LSD (1)
brand:
Delysid (historical, Sandoz, withdrawn 1965) (1) · Vyvanse, Elvanse (EU) (1)
classes: (Click arrow to add another value)
mechanism:
5-HT2A partial agonist (1) · '"`UNIQ--vote-00000013-QINU`"' Once converted, dextroamphetamine acts by displacing dopamine and norepinephrine from presynaptic vesicles via VMAT-2 and reversing DAT and NET transport, the shared mechanism of all amphetamine-class agents'"`UNIQ--ref-00000014-QINU`"'. (1)
uses:
None (1) · '"`UNIQ--vote-00000015-QINU`"', '"`UNIQ--vote-00000016-QINU`"' (1)
starting dose:
None (1) · ADHD: 30 mg PO once daily in the morning; titrate by 10-20 mg weekly to clinical effect. Binge-eating disorder: 30 mg/day, titrate to 50-70 mg/day (1)
preparations:
None (1) · Capsules 10, 20, 30, 40, 50, 60, 70 mg; chewable tablets 10, 20, 30, 40, 50, 60 mg (1)
fda max:
None (1) · 70 mg/day (1)
routes: (Click arrow to add another value)
onset:
1-2 hours (slower than immediate-release amphetamine because activation requires enzymatic cleavage in red blood cells) (1) · 30–60 minutes (1)
duration:
10-12 hours (smoother profile than immediate-release amphetamine salts) (1) · 8–12 hours (1)
halflife:
3–5 hours (1) · Parent lisdexamfetamine <1 hour; dextroamphetamine 10-12 hours after release'"`UNIQ--ref-00000017-QINU`"' (1)
bioavailability:
70–90% (oral) (1) · ~96% after red blood cell hydrolytic cleavage releases dextroamphetamine'"`UNIQ--ref-00000018-QINU`"' (1)
pregnancy:
Limited human data; the amphetamine class is associated with intrauterine growth restriction and neonatal withdrawal symptoms.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1) · Not established (1)
legal:
Schedule I (United States) (1) · [[USLegal:Schedule II|Schedule II controlled substance]] in US'"`UNIQ--ref-00000019-QINU`"' (1)

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