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Drilldown: Medicines

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Medicines > classes : Classic Psychedelic or Empathogen or [[:Category:NSAIDs|NSAID (naproxen)]]

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generic:
brand:
None (83) · Delysid (historical, Sandoz, withdrawn 1965) (1) · Treximet (1)
classes: (Click arrow to add another value)
mechanism:
5-HT2A agonist (26) · Potent 5-HT2A agonist (5) · LSD analogue; 5-HT2A agonist (4) · Prodrug of LSD; 5-HT2A agonist (4) · Monoamine releasing agent (3) · Serotonin releasing agent; 5-HT2A agonist (3) · Serotonin/norepinephrine/dopamine releasing agent (3) · Contains LSA (2) · Contains mescaline (2) · Serotonin releasing agent (2)
uses:
None (84) · '"`UNIQ--vote-000015D0-QINU`"' (1)
starting dose:
None (84) · 1 tablet (85/500 mg sumatriptan/naproxen) PO at migraine onset; may repeat after 2 hours if needed; maximum 2 tablets per 24 hours (1)
preparations:
None (84) · 85 mg sumatriptan / 500 mg naproxen sodium tablets; lower-dose 10/60 mg pediatric (Treximet pediatric) (1)
fda max:
None (84) · 2 tablets per 24 hours; ≤4 days per month to avoid medicine-overuse headache (1)
routes:
None (83) · Oral (2)
onset:
None (83) · 30–60 minutes (1) · Headache relief at 30-60 minutes (1)
duration:
None (83) · 4-8 hours (1) · 8–12 hours (1)
halflife:
None (83) · 3–5 hours (1) · Sumatriptan ~2.5 hours; naproxen 12-15 hours'"`UNIQ--ref-000015D1-QINU`"' (1)
bioavailability:
None (83) · 70–90% (oral) (1) · Sumatriptan ~15% (oral; substantial first-pass); naproxen ~95%'"`UNIQ--ref-000015D2-QINU`"' (1)
pregnancy:
None (83) · Avoid; NSAID-class restriction after 20 weeks (FDA 2020) and limited triptan pregnancy data.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1) · Not established (1)
legal:
None (83) · Schedule I (United States) (1) · [[USLegal:Prescription only|Rx-only]] in US. NSAID-class '''Boxed Warning''' for CV thrombotic events and GI bleeding; triptans contraindicated in coronary artery disease, peripheral vascular disease, uncontrolled hypertension, and recent ergot or MAOI use'"`UNIQ--ref-000015D3-QINU`"' (1)

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