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Medicines > classes : Classic Psychedelic or Neuroleptic or [[:Category:Dibenzothiazepines|Dibenzothiazepine]]

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generic:
brand:
None (69) · Delysid (historical, Sandoz, withdrawn 1965) (1) · Fanapt (1) · Geodon (1) · Inapsine (1) · Invega (1) · Latuda (1) · Loxitane (1) · Mellaril (1) · Moban (1) · Navane (1) · Orap (1) · Prolixin (1) · Saphris (1) · Seroquel (1) · Stelazine (1) · Thorazine (1) · Trilafon (1)
classes: (Click arrow to add another value)
mechanism:
5-HT2A agonist (26) · Potent 5-HT2A agonist (5) · LSD analogue; 5-HT2A agonist (4) · Phenothiazine D2 antagonist (4) · Prodrug of LSD; 5-HT2A agonist (4) · Contains LSA (2) · Contains mescaline (2)
uses:
None (85) · '"`UNIQ--vote-0000008F-QINU`"', '"`UNIQ--vote-00000090-QINU`"', '"`UNIQ--vote-00000091-QINU`"', '"`UNIQ--vote-00000092-QINU`"' (1)
starting dose:
None (85) · 25 mg (schizophrenia, immediate-release); 50 mg (bipolar mania, immediate-release); 50 mg (Seroquel XR, schizophrenia or bipolar) (1)
preparations:
None (85) · 25 mg, 50 mg, 100 mg, 200 mg, 300 mg, 400 mg immediate-release tablets; 50 mg, 150 mg, 200 mg, 300 mg, 400 mg extended-release tablets (Seroquel XR) (1)
fda max:
None (85) · 800 mg/day (1)
routes:
None (84) · Oral (2)
onset:
None (84) · 30-60 min (sedation); days to weeks (neuroleptic effect) (1) · 30–60 minutes (1)
duration:
None (84) · 6-8 h (immediate-release); 24 h (extended-release) (1) · 8–12 hours (1)
halflife:
None (84) · 3–5 hours (1) · ~6 h (parent compound, immediate-release); ~9-12 h (active metabolite N-desalkylquetiapine, also called norquetiapine) (1)
bioavailability:
None (84) · 70–90% (oral) (1) · Tablet ~100% relative to oral solution; extensive first-pass metabolism (1)
pregnancy:
None (84) · Not established (1) · Pregnancy categories were retired by FDA in 2015. Quetiapine has reassuring active-comparator cohort data without consistent teratogenic signal; among the preferred neuroleptics when treatment is clinically necessary in pregnancy. See pregnancy_details for the full citation set. (1)
legal:
None (84) · Schedule I (United States) (1) · [[USLegal:Prescription only|Prescription only]]; not a controlled substance (1)

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