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Drilldown: Medicines

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Medicines > classes : Classic Psychedelic or Research material or [[:Category:Surfactants|Surfactant]]

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generic:
brand:
None (141) · (none, never marketed) (1) · Colace (sodium), Surfak (calcium); many generics OTC (1) · Delysid (historical, Sandoz, withdrawn 1965) (1) · O-DSMT (1)
classes: (Click arrow to add another value)
mechanism:
5-HT2A agonist (27) · Monoamine releasing agent (9) · GABAA positive allosteric modulator (8) · CB1/CB2 agonist (7) · Dopamine/norepinephrine reuptake inhibitor (5) · Potent 5-HT2A agonist (5) · LSD analogue; 5-HT2A agonist (4) · Prodrug of LSD; 5-HT2A agonist (4) · Serotonin/norepinephrine/dopamine releasing agent (3) · Cathinone analogue; monoamine reuptake inhibitor (2) · Contains LSA (2) · Contains mescaline (2) · Dopamine and norepinephrine reuptake inhibitor (2) · NMDA antagonist (2) · Prodrug of GHB (2)
uses:
None (143) · No approved medical problem. Encountered as a designer/research benzodiazepine and, increasingly, as an adulterant in illicit opioid supplies. (1) · '"`UNIQ--vote-00001341-QINU`"', '"`UNIQ--vote-00001342-QINU`"' (1)
starting dose:
None (143) · 100-200 mg PO once or twice daily; pediatric weight-based (1) · No medical dose. Active recreational doses reported in the 0.5–1.5 mg range (similar potency to alprazolam). (1)
preparations:
None (143) · 50, 100, 250 mg capsules; 50 mg/5 mL syrup; OTC (1) · Illicit tablets ("bars"), powders, blotter, occasionally solutions. No pharmaceutical product exists. (1)
fda max:
None (143) · N/A (never approved) (1) · ~500 mg/d typical (1)
routes:
None (142) · intranasal; rectal and IV reported. (1) · Oral (3) · rectal (1) · sublingual (1)
onset:
None (142) · 1-3 days (1) · 30–60 minutes (1) · ~20–40 min PO; faster sublingual/intranasal. (1)
duration:
None (142) · 6–10 h subjective; full pharmacologic effect considerably longer. (1) · 8–12 hours (1) · Hours (1)
halflife:
None (142) · 3–5 hours (1) · Estimated ~12–17 h (some sources cite up to ~21 h); active metabolites prolong effect. (1) · Not meaningfully described (1)
bioavailability:
None (142) · 70–90% (oral) (1) · Local action; minimal systemic effect (1) · Not formally characterized in humans. (1)
pregnancy:
None (142) · Avoid. Benzodiazepines are associated with neonatal sedation, floppy-infant syndrome, and withdrawal; teratogenic signal weak but non-zero. Designer benzo with no safety data, assume worst-case. (1) · Generally considered safe.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1) · Not established (1)
legal:
None (143) · OTC in US (1) · Schedule I (United States) (1)

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