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Medicines > classes : Classic Psychedelic or Tryptamine or [[:Category:IBS_treatments|IBS-C treatment]]

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generic:
brand:
None (72) · Delysid (historical, Sandoz, withdrawn 1965) (1) · Linzess (1)
classes: (Click arrow to add another value)
mechanism:
1-acetyl-LSD; prodrug of LSD (1) · 5-HT2A agonist (27) · 5-HT2A agonist; 5-HT3 antagonist (1) · 5-HT2A agonist; D2 partial agonist (1) · 5-HT2A agonist; long duration (1) · 5-HT2A agonist; MAO inhibitor (1) · 5-HT2A agonist; milder than other 2C-x (1) · 5-HT2A agonist; minor psilocybin mushroom alkaloid (1) · 5-HT2A agonist; primarily auditory effects (1) · 5-HT2A agonist; sigma-1 agonist (1) · 5-HT2A partial agonist (1) · Contains bufotenin and DMT (1) · Contains LSA (2) · Contains mescaline (2) · Contains psilocybin and psilocin (1) · DMT + MAOI (harmine/harmaline); 5-HT2A agonist (1) · Extremely potent 5-HT2A agonist; vasoconstrictor (1) · Extremely potent 5-HT2A agonist; very long duration (1) · LSD analogue; 5-HT2A agonist (4) · Lysergic acid 2,4-dimethylazetidide; 5-HT2A agonist (1) · Lysergic acid hydroxyethylamide; 5-HT2A agonist (1) · Monoamine releasing agent; 5-HT2A agonist (1) · Monoamine releasing agent; 5-HT2A agonist; MAO inhibitor (1) · Potent 5-HT2A agonist (5) · Potent 5-HT2A agonist; no oral activity (1) · Potent 5-HT2A agonist; sigma-1 agonist (1) · Potent 5-HT2A agonist; very long duration (1) · Prodrug of 4-HO-DET; 5-HT2A agonist (1) · Prodrug of 4-HO-DiPT; 5-HT2A agonist (1) · Prodrug of 4-HO-MET; 5-HT2A agonist (1) · Prodrug of 4-HO-MiPT; 5-HT2A agonist (1) · Prodrug of LSD; 5-HT2A agonist (4) · Prodrug of psilocin; 5-HT2A agonist (1) · Serotonin/dopamine/norepinephrine releasing agent; 5-HT2A agonist (1) · Very potent 5-HT2A agonist; long duration (1) · '"`UNIQ--vote-00001197-QINU`"' Extracellular cGMP separately activates submucosal sensory afferents in a way that reduces visceral pain perception, distinguishing linaclotide from purely osmotic laxatives in IBS-C. Diarrhea is the dose-limiting effect'"`UNIQ--ref-00001198-QINU`"'. (1)
uses:
None (73) · '"`UNIQ--vote-00001199-QINU`"', '"`UNIQ--vote-0000119A-QINU`"', '"`UNIQ--vote-0000119B-QINU`"' (1)
starting dose:
None (73) · 145 mcg PO once daily for chronic idiopathic constipation; 290 mcg daily for IBS-C; pediatric 72 mcg daily (1)
preparations:
None (73) · 72, 145, 290 mcg capsules (1)
fda max:
None (73) · 290 mcg/d (1)
routes:
None (72) · Oral (2)
onset:
None (72) · 30–60 minutes (1) · Bowel movement within 1 week; abdominal pain improvement over weeks (1)
duration:
None (72) · 24 hours (1) · 8–12 hours (1)
halflife:
None (72) · 3–5 hours (1) · Not meaningfully described (negligible systemic absorption — the drug acts locally and is degraded in the GI tract)'"`UNIQ--ref-0000119C-QINU`"' (1)
bioavailability:
None (72) · 70–90% (oral) (1) · Negligible systemic absorption'"`UNIQ--ref-0000119D-QINU`"' (1)
pregnancy:
None (72) · Limited data; minimal systemic absorption likely renders fetal risk low.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1) · Not established (1)
legal:
None (72) · Schedule I (United States) (1) · [[USLegal:Prescription only|Rx-only]] in US. Carries a '''Boxed Warning''' contraindicating use in children <2 years (lethal dehydration in animal studies)'"`UNIQ--ref-0000119E-QINU`"' (1)

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