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Medicines > classes : Classic Psychedelic or dissociative or non-stimulant ADHD agent

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generic:
None (2)
brand:
None (86) · Delysid (historical, Sandoz, withdrawn 1965) (1) · DXM (1) · DXO (1) · Qelbree (1) · Spravato (1)
classes: (Click arrow to add another value)
mechanism:
5-HT2A agonist (26) · Potent 5-HT2A agonist (5) · LSD analogue; 5-HT2A agonist (4) · Prodrug of LSD; 5-HT2A agonist (4) · NMDA antagonist (3) · Contains LSA (2) · Contains mescaline (2) · NMDA antagonist; sigma receptor agonist (2)
uses:
None (89) · ADHD in children (6+), adolescents, and adults (FDA-approved 2021 for pediatric, 2022 for adult) (1) · Treatment-resistant depression (TRD) in adults, as adjunct to oral antidepressant (FDA-approved March 2019). Depressive symptoms in adults with MDD with acute suicidal ideation or behavior (FDA-approved Aug 2020). (1)
starting dose:
None (89) · Induction (TRD): 56 mg intranasal twice weekly × 4 weeks. Maintenance: 56-84 mg once weekly × 4 weeks, then 56-84 mg every 1-2 weeks. For acute suicidality: 84 mg twice weekly × 4 weeks. Administered under medical supervision in REMS-certified site. (1) · Pediatric 6-11: 100 mg PO daily, titrate weekly to max 400 mg. Adolescent 12-17: 200 mg, max 400 mg. Adult: 200 mg, max 600 mg. (1)
preparations:
None (89) · 100 mg, 150 mg, 200 mg extended-release capsules (can be sprinkled on food) (1) · 28 mg/device (each dose uses 2 devices) (1)
fda max:
None (89) · 400 mg/d (pediatric); 600 mg/d (adult) (1) · 84 mg per session (1)
routes:
None (88) · Intranasal (under direct medical supervision) (1) · Oral (2)
onset:
None (88) · 30–60 minutes (1) · ADHD symptom improvement reported within 1-2 weeks (faster than atomoxetine which takes 4-6 weeks) (1) · Within hours of first administration (1)
duration:
None (88) · 8–12 hours (1) · Acute effect ~24 hours; cumulative effect builds with repeated dosing (1) · Daily dosing (1)
halflife:
None (88) · 3–5 hours (1) · ~7 hours (1) · ~7-12 hours (1)
bioavailability:
None (88) · 70–90% (oral) (1) · Adequate oral bioavailability with extended-release formulation (1) · ~48% intranasal (1)
pregnancy:
None (88) · Avoid; may cause fetal harm (1) · Limited data (1) · Not established (1)
legal:
None (88) · Rx, '''not a controlled substance''' (no DEA scheduling) (1) · Rx, Schedule III (US). REMS program required. (1) · Schedule I (United States) (1)

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