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Drilldown: Medicines

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Medicines > classes : Classic Psychedelic or secondary amine)]] & routes: Oral

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generic:
LSD (1) · Nortriptyline (hydrochloride) (1)
brand:
Delysid (historical, Sandoz, withdrawn 1965) (1) · Pamelor (US brand discontinued; generic widely available), Aventyl (1)
classes: (Click arrow to add another value)
mechanism:
5-HT2A partial agonist (1) · '"`UNIQ--vote-00000019-QINU`"' Therapeutic plasma-level monitoring is standard practice for TCAs given the narrow therapeutic index and the established plasma-level-efficacy correlation. CYP2D6 substrate; CPIC PGx guidance applies for dose individualization'"`UNIQ--ref-0000001A-QINU`"'. (1)
uses:
None (1) · '"`UNIQ--vote-0000001B-QINU`"', '"`UNIQ--vote-0000001C-QINU`"', '"`UNIQ--vote-0000001D-QINU`"', '"`UNIQ--vote-0000001E-QINU`"', '"`UNIQ--vote-0000001F-QINU`"' (1)
starting dose:
None (1) · Depression: 25 mg PO TID-QID or 75 mg at bedtime, titrate to 75-150 mg/day. Neuropathic pain: 10-25 mg at bedtime, titrate to 50-100 mg/day. Elderly: 10 mg at bedtime (Beers-list cautions, though less than amitriptyline) (1)
preparations:
None (1) · Capsules 10, 25, 50, 75 mg; oral solution 10 mg/5 mL (1)
fda max:
None (1) · 150 mg/day; therapeutic plasma-level monitoring recommended (target 50-150 ng/mL window) (1)
routes: (Click arrow to add another value)
onset:
30–60 minutes (1) · Pain and migraine prophylaxis effect 1-4 weeks; antidepressant effect 4-6 weeks (1)
duration:
24 hours (HS dosing) (1) · 8–12 hours (1)
halflife:
18-44 hours'"`UNIQ--ref-00000020-QINU`"' (1) · 3–5 hours (1)
bioavailability:
70–90% (oral) (1) · ~50% (oral)'"`UNIQ--ref-00000021-QINU`"' (1)
pregnancy:
Not established (1) · TCA class signal; limited human data specific to nortriptyline.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
Schedule I (United States) (1) · [[USLegal:Prescription only|Rx-only]] in US. Carries the antidepressant '''Boxed Warning''' for suicidality in children, adolescents, and young adults'"`UNIQ--ref-00000022-QINU`"' (1)

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