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Drilldown: Medicines

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Medicines > classes : Dissociative or [[:Category:Selective Serotonin Reuptake Inhibitors (SSRIs)|SSRI]]

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generic:
None (1) · 2-FDCK (1) · 3-HO-PCE (1) · 3-HO-PCP (1) · 3-MeO-PCE (1) · 3-MeO-PCP (1) · 4-MeO-PCP (1) · Deschloroketamine (1) · Dextromethorphan (1) · Dextrorphan (1) · Diphenidine (1) · Ephenidine (1) · Eticyclidine (1) · Fluoxetine (1) · Ibogaine (1) · Methoxetamine (1) · Nitrous oxide (1) · O-PCE (1) · Salvia divinorum (1) · Salvinorin A (1) · Xenon (1)
brand:
None (17) · DXM (1) · DXO (1) · Prozac (1) · Spravato (1)
classes: (Click arrow to add another value)
mechanism:
None (1) · Active metabolite of DXM; NMDA antagonist (1) · Contains salvinorin A (1) · Kappa-opioid agonist; NMDA antagonist; SERT/DAT/NET inhibitor (1) · Kappa-opioid receptor agonist (1) · NMDA antagonist (3) · NMDA antagonist; endogenous opioid releaser (1) · NMDA antagonist; fluorinated ketamine analogue (1) · NMDA antagonist; kappa-opioid agonist (1) · NMDA antagonist; ketamine analogue (1) · NMDA antagonist; more stimulating than PCP (1) · NMDA antagonist; opioid agonist (1) · NMDA antagonist; potent opioid agonist (1) · NMDA antagonist; SERT inhibitor; sigma-1 agonist (1) · NMDA antagonist; sigma receptor agonist (2) · NMDA antagonist; sigma receptor agonist; dopaminergic (1) · NMDA antagonist; sigma-1 agonist; serotonin reuptake inhibitor (1) · TrkB/BDNF'"`UNIQ--ref-00000040-QINU`"' '"`UNIQ--vote-00000041-QINU`"' (1)
uses:
None (19) · Treatment-resistant depression (TRD) in adults, as adjunct to oral antidepressant (FDA-approved March 2019). Depressive symptoms in adults with MDD with acute suicidal ideation or behavior (FDA-approved Aug 2020). (1) · '"`UNIQ--vote-00000042-QINU`"', '"`UNIQ--vote-00000043-QINU`"', '"`UNIQ--vote-00000044-QINU`"' (1)
starting dose:
None (19) · 10 mg (1) · Induction (TRD): 56 mg intranasal twice weekly × 4 weeks. Maintenance: 56-84 mg once weekly × 4 weeks, then 56-84 mg every 1-2 weeks. For acute suicidality: 84 mg twice weekly × 4 weeks. Administered under medical supervision in REMS-certified site. (1)
preparations:
None (19) · 10 mg, 20 mg, 40 mg caps (1) · 28 mg/device (each dose uses 2 devices) (1)
fda max:
None (19) · 40 mg/d (1) · 84 mg per session (1)
routes:
None (19) · Intranasal (under direct medical supervision) (1) · Oral (1)
onset:
None (20) · Within hours of first administration (1)
duration:
None (19) · Acute effect ~24 hours; cumulative effect builds with repeated dosing (1) · Very long (1)
halflife:
None (19) · 1–4 days (7–15 days for norfluoxetine) (1) · ~7-12 hours (1)
bioavailability:
None (19) · 70–90% (oral) (1) · ~48% intranasal (1)
pregnancy:
None (19) · Avoid; may cause fetal harm (1) · Category C'"`UNIQ--ref-00000045-QINU`"' (1)
legal:
None (19) · Rx, Schedule III (US). REMS program required. (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

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