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Drilldown: Medicines

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Medicines > generic: None & classes : Dissociative or Gepant

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generic: (Click arrow to add another value)
brand:
Spravato (1) · Zavzpret (zavegepant) (1)
classes: (Click arrow to add another value)
mechanism:
None (1) · Small-molecule CGRP receptor antagonist; intranasal formulation (1)
uses:
Acute treatment of migraine with or without aura in adults (1) · Treatment-resistant depression (TRD) in adults, as adjunct to oral antidepressant (FDA-approved March 2019). Depressive symptoms in adults with MDD with acute suicidal ideation or behavior (FDA-approved Aug 2020). (1)
starting dose:
10 mg (one spray) intranasally in one nostril (1) · Induction (TRD): 56 mg intranasal twice weekly × 4 weeks. Maintenance: 56-84 mg once weekly × 4 weeks, then 56-84 mg every 1-2 weeks. For acute suicidality: 84 mg twice weekly × 4 weeks. Administered under medical supervision in REMS-certified site. (1)
preparations:
10 mg/spray nasal solution (1) · 28 mg/device (each dose uses 2 devices) (1)
fda max:
10 mg per 24 h (1) · 84 mg per session (1)
routes:
Intranasal (1) · Intranasal (under direct medical supervision) (1)
onset:
Pain relief reported within 15 min in trials (1) · Within hours of first administration (1)
duration:
Acute effect ~24 hours; cumulative effect builds with repeated dosing (1) · ~48 h sustained pain freedom in responders (1)
halflife:
~6.6 h (1) · ~7-12 hours (1)
bioavailability:
~48% intranasal (1) · ~5% intranasal (1)
pregnancy:
Avoid; may cause fetal harm (1) · Limited data; avoid (1)
legal:
Rx (1) · Rx, Schedule III (US). REMS program required. (1)

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