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Drilldown: Medicines

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Medicines > classes : Empathogen or Research material or [[:Category:Cholesterol_absorption_inhibitors|Cholesterol absorption inhibitor]]

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generic:
brand:
None (140) · (none, never marketed) (1) · O-DSMT (1) · Zetia (1)
classes: (Click arrow to add another value)
mechanism:
5-HT2A agonist (26) · Monoamine releasing agent (10) · GABAA positive allosteric modulator (8) · CB1/CB2 agonist (7) · Dopamine/norepinephrine reuptake inhibitor (5) · Potent 5-HT2A agonist (5) · LSD analogue; 5-HT2A agonist (4) · Prodrug of LSD; 5-HT2A agonist (4) · Serotonin releasing agent; 5-HT2A agonist (3) · Serotonin/norepinephrine/dopamine releasing agent (3) · Cathinone analogue; monoamine reuptake inhibitor (2) · Dopamine and norepinephrine reuptake inhibitor (2) · NMDA antagonist (2) · Prodrug of GHB (2) · Serotonin releasing agent (2)
uses:
None (141) · No approved medical problem. Encountered as a designer/research benzodiazepine and, increasingly, as an adulterant in illicit opioid supplies. (1) · '"`UNIQ--vote-0000044C-QINU`"', '"`UNIQ--vote-0000044D-QINU`"', '"`UNIQ--vote-0000044E-QINU`"', '"`UNIQ--vote-0000044F-QINU`"' (1)
starting dose:
None (141) · 10 mg PO once daily, with or without food (1) · No medical dose. Active recreational doses reported in the 0.5–1.5 mg range (similar potency to alprazolam). (1)
preparations:
None (141) · 10 mg tablet; also as fixed-dose combinations with simvastatin (Vytorin) and atorvastatin (Liptruzet, withdrawn US 2015 but generics exist) (1) · Illicit tablets ("bars"), powders, blotter, occasionally solutions. No pharmaceutical product exists. (1)
fda max:
None (141) · 10 mg/d (1) · N/A (never approved) (1)
routes:
None (141) · intranasal; rectal and IV reported. (1) · Oral (2) · sublingual (1)
onset:
None (141) · LDL lowering within 2 weeks (1) · ~20–40 min PO; faster sublingual/intranasal. (1)
duration:
None (141) · 24 hours (1) · 6–10 h subjective; full pharmacologic effect considerably longer. (1)
halflife:
None (141) · Estimated ~12–17 h (some sources cite up to ~21 h); active metabolites prolong effect. (1) · ~22 hours (parent + active glucuronide)'"`UNIQ--ref-00000450-QINU`"' (1)
bioavailability:
None (141) · Not formally characterized in humans. (1) · Variable (oral; rapidly conjugated to active glucuronide; food does not affect)'"`UNIQ--ref-00000451-QINU`"' (1)
pregnancy:
None (141) · Avoid. Benzodiazepines are associated with neonatal sedation, floppy-infant syndrome, and withdrawal; teratogenic signal weak but non-zero. Designer benzo with no safety data, assume worst-case. (1) · Limited data; generally avoided particularly in combination with statin.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
None (142) · [[USLegal:Prescription only|Rx-only]] in US (1)

Showing below up to 149 results in range #1 to #149.

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