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Medicines > classes : Empathogen or weak μ-agonist with serotonin/norepinephrine reuptake inhibition)]] & fda max: 400 mg/day (IR, adult); 300 mg/day (ER); 300 mg/day in elderly >75 years

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generic:
Tramadol (1)
brand:
Ultram (IR), Ultram ER, ConZip ER (1)
classes: (Click arrow to add another value)
mechanism:
None (1)
uses:
'"`UNIQ--vote-00000020-QINU`"', '"`UNIQ--vote-00000021-QINU`"', '"`UNIQ--vote-00000022-QINU`"', '"`UNIQ--vote-00000023-QINU`"' (1)
starting dose:
IR: 25-50 mg PO every 4-6 hours as needed, titrate as tolerated. ER: 100 mg PO once daily, titrate by 100 mg every 5 days (1)
preparations:
IR tablets 50 mg; ER tablets 100, 200, 300 mg (Ultram ER, ConZip); oral solution 5 mg/mL; combination products with acetaminophen (Ultracet) (1)
fda max: (Click arrow to add another value)
routes:
Oral (1)
onset:
30-60 minutes (IR) (1)
duration:
4-6 hours (IR); 24 hours (ER) (1)
halflife:
Tramadol 6-7 hours; M1 active metabolite 7-9 hours'"`UNIQ--ref-00000024-QINU`"' (1)
bioavailability:
~75% (IR, rises with multi-dose administration due to saturable first-pass)'"`UNIQ--ref-00000025-QINU`"' (1)
pregnancy:
Chronic third-trimester exposure produces neonatal opioid withdrawal syndrome and respiratory depression at delivery.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Schedule IV|Schedule IV controlled substance]] in US (federally scheduled 2014); some states schedule higher'"`UNIQ--ref-00000026-QINU`"' (1)

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