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Drilldown: Medicines

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Medicines > classes : NDRI or Tryptamine & routes: Oral

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generic:
Dexmethylphenidate (1) · Methylphenidate (1)
brand:
Focalin, Focalin XR (1) · Ritalin, Ritalin LA, Concerta, Metadate CD, Daytrana, Quillivant XR (1)
classes: (Click arrow to add another value)
mechanism:
Norepinephrine–dopamine reuptake inhibition (DAT, NET) (1) · Norepinephrine–dopamine reuptake inhibition (DAT, NET), d-threo enantiomer of methylphenidate (1)
uses:
ADHD, narcolepsy (1) · '"`UNIQ--vote-00000150-QINU`"', '"`UNIQ--vote-00000151-QINU`"' (1)
starting dose:
None (2)
preparations:
None (2)
fda max:
None (2)
routes: (Click arrow to add another value)
onset:
20–60 min (oral) (1) · 30–60 min (1)
duration:
IR 3–5 h; LA/SR 6–8 h; Concerta 10–12 h; Daytrana ~9 h wear time (1) · IR 4–6 h; XR 8–12 h (1)
halflife:
2.2 h (IR parent); ~3 h (XR parent) (1) · 2–3 h (parent compound) (1)
bioavailability:
~22–25% (1) · ~30% (high first-pass) (1)
pregnancy:
Category C (1) · Pregnancy categories were retired by FDA in 2015. Limited reproductive data with small observational signal for cardiac malformations; risk-benefit decision, with many patients deferring ADHD treatment during pregnancy. See pregnancy_details for the full discussion. (1)
legal:
Schedule II (2)

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