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Medicines > classes : Neuroleptic or [[:Category:Calcium_channel_blockers|Calcium channel blocker]]

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generic:
Amlodipine (1) · Asenapine (1) · Chlorpromazine (1) · Droperidol (1) · Fluphenazine (1) · Iloperidone (1) · Loxapine (1) · Lurasidone (1) · Molindone (1) · Paliperidone (1) · Perphenazine (1) · Pimozide (1) · Thioridazine (1) · Thiothixene (1) · Trifluoperazine (1) · Ziprasidone (1)
brand:
Fanapt (1) · Geodon (1) · Inapsine (1) · Invega (1) · Latuda (1) · Loxitane (1) · Mellaril (1) · Moban (1) · Navane (1) · Norvasc, Katerzia (1) · Orap (1) · Prolixin (1) · Saphris (1) · Stelazine (1) · Thorazine (1) · Trilafon (1)
classes: (Click arrow to add another value)
mechanism:
Butyrophenone D2 antagonist (1) · D2 receptor antagonist; also H1, alpha-1, muscarinic antagonist (1) · D2/5-HT2A antagonist (1) · D2/5-HT2A antagonist; 5-HT7 antagonist (1) · D2/5-HT2A antagonist; active metabolite of risperidone (1) · D2/5-HT2A antagonist; SRI and NRI (1) · Dibenzoxazepine D2/5-HT2 antagonist (1) · Dihydroindolone D2 antagonist (1) · Diphenylbutylpiperidine D2 antagonist (1) · Multi-receptor antagonist (D2, 5-HT2A, H1, alpha) (1) · Phenothiazine D2 antagonist (4) · Thioxanthene D2 antagonist (1) · '"`UNIQ--vote-00000073-QINU`"' The long half-life gives smooth, once-daily BP control with low rebound. CYP3A4 substrate; pedal edema is the characteristic, dose-related, non-fluid-overload side effect'"`UNIQ--ref-00000074-QINU`"'. (1)
uses:
None (15) · '"`UNIQ--vote-00000075-QINU`"', '"`UNIQ--vote-00000076-QINU`"', '"`UNIQ--vote-00000077-QINU`"' (1)
starting dose:
None (15) · 2.5-5 mg PO once daily; titrate to 10 mg/d (1)
preparations:
None (15) · 2.5, 5, 10 mg tablets; 1 mg/mL oral suspension (1)
fda max:
None (15) · 10 mg/d (1)
routes:
None (15) · Oral (1)
onset:
None (15) · BP effect within 24 hours; full effect at 1-2 weeks (long half-life) (1)
duration:
None (15) · 24 hours (1)
halflife:
None (15) · 30-50 hours'"`UNIQ--ref-00000078-QINU`"' (1)
bioavailability:
None (15) · 64-90% (oral; not affected by food)'"`UNIQ--ref-00000079-QINU`"' (1)
pregnancy:
None (15) · Limited data; case series and registries suggest no major teratogenicity but other antihypertensives (labetalol, nifedipine) are typically preferred.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
None (15) · [[USLegal:Prescription only|Rx-only]] in US (1)

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