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Medicines > generic: Codeine & classes : Norepinephrine-dopamine reuptake inhibitor (NDRI) or Opioid

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generic: (Click arrow to add another value)
brand:
None (1) · (multiple, generic dominant) (1)
classes: (Click arrow to add another value)
mechanism:
Mu-opioid receptor agonist; prodrug (metabolized to morphine) (1) · Prodrug; converted to [[Morphine|morphine]] by [[Enzyme:CYP2D6|CYP2D6]] for analgesic action. (1)
uses:
None (1) · Mild to moderate pain; cough suppression (low-dose). (1)
starting dose:
None (1) · Adult: 15–60 mg every 4 hours as needed. (1)
preparations:
None (1) · Tablet (15, 30, 60 mg); oral solution; combination products (with [[Acetaminophen|acetaminophen]] or ibuprofen). (1)
fda max:
None (1) · 360 mg/day (1)
routes:
None (1) · PO (only formulation marketed in the US). (1)
onset:
None (1) · 30–60 min (PO) (1)
duration:
None (1) · 4–6 hours (1)
halflife:
None (1) · 2.5–3 hours (1)
bioavailability:
None (1) · ~50% (variable, CYP2D6-dependent for analgesic effect). (1)
pregnancy:
None (1) · Avoid; risk of neonatal opioid withdrawal with chronic use; UM-mother breastfeeding contraindicated. (1)
legal:
None (1) · US Schedule II (single-entity); Schedule III–V (combination products by content). (1)

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