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Medicines > classes : Norepinephrine-dopamine reuptake inhibitor (NDRI) or Phenethylamine & routes: Oral

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generic:
None (1) · 2C-B (1)
brand:
Nexus, Eroxan (historical, late-1980s through mid-1990s) (1) · Sunosi (1)
classes: (Click arrow to add another value)
mechanism:
5-HT2A partial agonist (1) · Selective dopamine and norepinephrine reuptake inhibitor (DAT and NET inhibition). Unlike amphetamine, does not significantly release monoamines, pure reuptake inhibition. (1)
uses:
None (1) · Excessive daytime sleepiness in adults with narcolepsy or obstructive sleep apnea (OSA) (1)
starting dose:
None (1) · Narcolepsy: 75 mg PO once daily upon awakening, titrate every 3 days. OSA: 37.5 mg PO once daily, titrate. (1)
preparations:
None (1) · 75 mg, 150 mg tablets (1)
fda max:
None (1) · 150 mg/d (1)
routes: (Click arrow to add another value)
onset:
45-75 min (oral) (1) · ~30-60 min (1)
duration:
4-8 h (1) · ~9 hours (1)
halflife:
Not well characterized (1) · ~7.1 hours (1)
bioavailability:
Not well characterized (1) · ~95% (1)
pregnancy:
Limited data; pregnancy exposure registry available (1) · Not established (1)
legal:
Rx, Schedule IV (US) (1) · [[USLegal:DEA Schedule I|Schedule I]] (United States) (1)

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