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Medicines > classes : Opioid or Selective 5HT2A inverse agonist (with weaker 5HT2C inverse agonism) & fda max: 360 mg/day

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generic:
Codeine (1)
brand:
(multiple, generic dominant) (1)
classes: (Click arrow to add another value)
mechanism:
Prodrug; converted to [[Morphine|morphine]] by [[Enzyme:CYP2D6|CYP2D6]] for analgesic action. (1)
uses:
Mild to moderate pain; cough suppression (low-dose). (1)
starting dose:
Adult: 15–60 mg every 4 hours as needed. (1)
preparations:
Tablet (15, 30, 60 mg); oral solution; combination products (with [[Acetaminophen|acetaminophen]] or ibuprofen). (1)
fda max: (Click arrow to add another value)
routes:
PO (only formulation marketed in the US). (1)
onset:
30–60 min (PO) (1)
duration:
4–6 hours (1)
halflife:
2.5–3 hours (1)
bioavailability:
~50% (variable, CYP2D6-dependent for analgesic effect). (1)
pregnancy:
Avoid; risk of neonatal opioid withdrawal with chronic use; UM-mother breastfeeding contraindicated. (1)
legal:
US Schedule II (single-entity); Schedule III–V (combination products by content). (1)

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