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Medicines > classes : Phenethylamine or Stimulant or [[:Category:Aminoglycosides|Aminoglycoside antibiotic]]

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generic:
brand:
None (67) · Benzedrex (1) · Nexus, Eroxan (historical, late-1980s through mid-1990s) (1) · Tobrex (ophthalmic), Tobi, Tobi Podhaler, Bethkis (inhaled, cystic fibrosis), generic IV (1)
classes: (Click arrow to add another value)
mechanism:
5-HT2A agonist (12) · Monoamine releasing agent (8) · Dopamine/norepinephrine reuptake inhibitor (5) · Potent 5-HT2A agonist (5) · Cathinone analogue; monoamine reuptake inhibitor (2) · Dopamine and norepinephrine reuptake inhibitor (2) · Norepinephrine–dopamine reuptake inhibitor (2)
uses:
None (69) · '"`UNIQ--vote-000010AF-QINU`"', '"`UNIQ--vote-000010B0-QINU`"', '"`UNIQ--vote-000010B1-QINU`"', '"`UNIQ--vote-000010B2-QINU`"' (1)
starting dose:
None (69) · IV: traditional 1-1.7 mg/kg q8h or extended-interval 5-7 mg/kg q24h with target-trough monitoring; inhaled CF 300 mg BID × 28 days on / 28 days off; ophthalmic 1-2 drops in affected eye(s) q4h (1)
preparations:
None (69) · IV 10 mg/mL, 40 mg/mL; inhaled 300 mg/5 mL solution (Tobi, Bethkis); Podhaler dry powder; 0.3% ophthalmic solution and ointment (1)
fda max:
None (69) · IV: monitored by levels (trough <1 mg/L for extended-interval; <2 mg/L for traditional) (1)
routes:
None (68) · IM (1) · inhaled (1) · insufflated (1) · intravitreal (1) · IV (1) · ophthalmic (1) · Oral (1) · PR (1)
onset:
None (68) · 45-75 min (oral) (1) · Hours (systemic); minutes (ophthalmic) (1)
duration:
None (68) · 4-8 h (1) · 6-12 hours systemic (1)
halflife:
None (68) · 2-3 hours (normal renal function); markedly prolonged in renal impairment'"`UNIQ--ref-000010B3-QINU`"' (1) · Not well characterized (1)
bioavailability:
None (68) · IV/IM ~100%; inhaled: minimal systemic; oral: negligible (not used orally for systemic infection)'"`UNIQ--ref-000010B4-QINU`"' (1) · Not well characterized (1)
pregnancy:
None (68) · Aminoglycoside-class ototoxicity in fetal cochlea is documented; use only when alternatives have failed.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1) · Not established (1)
legal:
None (68) · [[USLegal:DEA Schedule I|Schedule I]] (United States) (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

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