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Medicines > classes : Phenethylamine or Stimulant or [[:Category:Disaccharides|Non-absorbable disaccharide]]

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generic:
brand:
None (67) · Benzedrex (1) · Kristalose, Constulose, Generlac, Enulose (1) · Nexus, Eroxan (historical, late-1980s through mid-1990s) (1)
classes: (Click arrow to add another value)
mechanism:
5-HT2A agonist (12) · Monoamine releasing agent (8) · Dopamine/norepinephrine reuptake inhibitor (5) · Potent 5-HT2A agonist (5) · Cathinone analogue; monoamine reuptake inhibitor (2) · Dopamine and norepinephrine reuptake inhibitor (2) · Norepinephrine–dopamine reuptake inhibitor (2)
uses:
None (69) · '"`UNIQ--vote-00000F5C-QINU`"', '"`UNIQ--vote-00000F5D-QINU`"' (1)
starting dose:
None (69) · Constipation: 15-30 mL PO daily (titrate to 1-2 soft stools/day); hepatic encephalopathy: 20-30 g (30-45 mL) PO/PR every 1-2 hours acutely until soft stools, then BID-QID to target 2-3 soft stools/day (1)
preparations:
None (69) · 10 g/15 mL solution (Constulose); 10 g, 20 g powder packets (Kristalose) (1)
fda max:
None (69) · Indication-specific; HE may require high-volume dosing (1)
routes:
None (68) · especially in acute HE) (1) · insufflated (1) · Oral (2) · PR (1) · rectal (enema (1)
onset:
None (68) · 45-75 min (oral) (1) · Constipation: 24-48 hours; HE: ammonia reduction within hours of stool production (1)
duration:
None (68) · 4-8 h (1) · Hours (1)
halflife:
None (68) · Not meaningfully described — lactulose is not significantly absorbed (1) · Not well characterized (1)
bioavailability:
None (68) · <3% systemic absorption (the basis of the safety and mechanism)'"`UNIQ--ref-00000F5E-QINU`"' (1) · Not well characterized (1)
pregnancy:
None (68) · Generally considered safe (minimal systemic absorption).<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1) · Not established (1)
legal:
None (68) · [[USLegal:DEA Schedule I|Schedule I]] (United States) (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

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